The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm
Abstract The preoperative accurate diagnosis is difficult in the patients with intraductal papillary mucinous neoplasm (IPMN). The aim of the present study was to elucidate the roles of systemic inflammation responses and nutritional status indexes in IPMN. High-grade dysplasia was classified as a m...
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Nature Portfolio
2021
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oai:doaj.org-article:1385add8bf0f40fa85a701e317fdc94a2021-12-02T14:01:20ZThe prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm10.1038/s41598-020-79583-62045-2322https://doaj.org/article/1385add8bf0f40fa85a701e317fdc94a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79583-6https://doaj.org/toc/2045-2322Abstract The preoperative accurate diagnosis is difficult in the patients with intraductal papillary mucinous neoplasm (IPMN). The aim of the present study was to elucidate the roles of systemic inflammation responses and nutritional status indexes in IPMN. High-grade dysplasia was classified as a malignant neoplasm in the study. We retrospectively reviewed 155 patients who underwent pancreatectomy. The correlation between the clinical factors and several indexes of a systemic inflammation response and nutritional status was analyzed. Among the biomarkers, prognostic nutritional index (PNI) value of malignant IPMN patients was significantly lower than that of benign IPMN patients (P = 0.023), whereas PNI was not significant predictor for malignant IPMN. The multivariate analysis showed that a PNI < 43.5 (odds ratio [OR] 16.1, 95% CI 1.88–138.5, P = 0.011) and a carbohydrate antigen (CA) 19–9 level > 22.5 U/mL (OR 6.64, 95% CI 1.73–25.6, P = 0.006) were significant independent predictors of the presence of lymph node metastasis (LNM). Our scoring system developed based on these two factors. Patients with a score of 0 had no LNM and zero disease-related death. The present study suggested the roles of PNI on the IPMN patients who undergo curative pancreatectomy.Yukiyasu OkamuraTeiichi SugiuraTakaaki ItoYusuke YamamotoRyo AshidaKatsuhisa OhgiKeiko SasakiHiroto NarimatsuKatsuhiko UesakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Yukiyasu Okamura Teiichi Sugiura Takaaki Ito Yusuke Yamamoto Ryo Ashida Katsuhisa Ohgi Keiko Sasaki Hiroto Narimatsu Katsuhiko Uesaka The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| description |
Abstract The preoperative accurate diagnosis is difficult in the patients with intraductal papillary mucinous neoplasm (IPMN). The aim of the present study was to elucidate the roles of systemic inflammation responses and nutritional status indexes in IPMN. High-grade dysplasia was classified as a malignant neoplasm in the study. We retrospectively reviewed 155 patients who underwent pancreatectomy. The correlation between the clinical factors and several indexes of a systemic inflammation response and nutritional status was analyzed. Among the biomarkers, prognostic nutritional index (PNI) value of malignant IPMN patients was significantly lower than that of benign IPMN patients (P = 0.023), whereas PNI was not significant predictor for malignant IPMN. The multivariate analysis showed that a PNI < 43.5 (odds ratio [OR] 16.1, 95% CI 1.88–138.5, P = 0.011) and a carbohydrate antigen (CA) 19–9 level > 22.5 U/mL (OR 6.64, 95% CI 1.73–25.6, P = 0.006) were significant independent predictors of the presence of lymph node metastasis (LNM). Our scoring system developed based on these two factors. Patients with a score of 0 had no LNM and zero disease-related death. The present study suggested the roles of PNI on the IPMN patients who undergo curative pancreatectomy. |
| format |
article |
| author |
Yukiyasu Okamura Teiichi Sugiura Takaaki Ito Yusuke Yamamoto Ryo Ashida Katsuhisa Ohgi Keiko Sasaki Hiroto Narimatsu Katsuhiko Uesaka |
| author_facet |
Yukiyasu Okamura Teiichi Sugiura Takaaki Ito Yusuke Yamamoto Ryo Ashida Katsuhisa Ohgi Keiko Sasaki Hiroto Narimatsu Katsuhiko Uesaka |
| author_sort |
Yukiyasu Okamura |
| title |
The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| title_short |
The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| title_full |
The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| title_fullStr |
The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| title_full_unstemmed |
The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| title_sort |
prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1385add8bf0f40fa85a701e317fdc94a |
| work_keys_str_mv |
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