The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia

Stress-induced analgesia (SIA) is a well-known phenomenon, in which mechanisms of development opioid and non-opioid components take part. The endogenous cannabinoid system (ECS) takes part in the non-opioid pathways and modulates nociception. Nitric oxide (NO) is also proverbial to interfere with pa...

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Autores principales:	Nocheva H., Sabit Z., Grigorov E.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	endogenous cannabinoid system (ecs) nitricoxidergic system cold stress heat stress stress-induced analgesia (sia) Medicine R
Acceso en línea:	https://doaj.org/article/1386bcbd34d348d5aa293314adc89fba
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spelling	oai:doaj.org-article:1386bcbd34d348d5aa293314adc89fba2021-12-02T19:11:31ZThe Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia0324-175010.2478/amb-2021-0005https://doaj.org/article/1386bcbd34d348d5aa293314adc89fba2021-04-01T00:00:00Zhttps://doi.org/10.2478/amb-2021-0005https://doaj.org/toc/0324-1750Stress-induced analgesia (SIA) is a well-known phenomenon, in which mechanisms of development opioid and non-opioid components take part. The endogenous cannabinoid system (ECS) takes part in the non-opioid pathways and modulates nociception. Nitric oxide (NO) is also proverbial to interfere with pain perception. The present study was performed to investigate the effects from interaction between the ECS and NO after heat (heat stress) or cold (cold stress) exposure. Male Wistar rats subjected to one hour of heat or cold stress were injected with different combinations of cannabinoid receptor type 1 (CB1) agonist anandamide (AEA) or antagonist (AM251) along with NO-donor, NO-precursor or inhibitor of the NO-synthase (NOS). Nociception was evaluated using Paw pressure (Randall-Selitto) test. The results showed that AEA-administration immediately after the end of stress let to a tendency to increase cold-SIA, but decreased heat-SIA. AEA along with NO-donor increased both cold- and heat-SIA but to a different degree. AM251 and NOS-inhibitor decreased SIA. Our experiments confirmed that the endogenous cannabinoid and the nitricoxidergic systems interact between them in the modulation of SIA. The ECS exerts a more prominent influence on cold rather than heat SIA. Differences in modulation probably depend on the type of stress, due to the different participation of ECS in the mechanisms of SIA development.Nocheva H.Sabit Z.Grigorov E.Sciendoarticleendogenous cannabinoid system (ecs)nitricoxidergic systemcold stressheat stressstress-induced analgesia (sia)MedicineRENActa Medica Bulgarica, Vol 48, Iss 1, Pp 34-39 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endogenous cannabinoid system (ecs) nitricoxidergic system cold stress heat stress stress-induced analgesia (sia) Medicine R
spellingShingle	endogenous cannabinoid system (ecs) nitricoxidergic system cold stress heat stress stress-induced analgesia (sia) Medicine R Nocheva H. Sabit Z. Grigorov E. The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
description	Stress-induced analgesia (SIA) is a well-known phenomenon, in which mechanisms of development opioid and non-opioid components take part. The endogenous cannabinoid system (ECS) takes part in the non-opioid pathways and modulates nociception. Nitric oxide (NO) is also proverbial to interfere with pain perception. The present study was performed to investigate the effects from interaction between the ECS and NO after heat (heat stress) or cold (cold stress) exposure. Male Wistar rats subjected to one hour of heat or cold stress were injected with different combinations of cannabinoid receptor type 1 (CB1) agonist anandamide (AEA) or antagonist (AM251) along with NO-donor, NO-precursor or inhibitor of the NO-synthase (NOS). Nociception was evaluated using Paw pressure (Randall-Selitto) test. The results showed that AEA-administration immediately after the end of stress let to a tendency to increase cold-SIA, but decreased heat-SIA. AEA along with NO-donor increased both cold- and heat-SIA but to a different degree. AM251 and NOS-inhibitor decreased SIA. Our experiments confirmed that the endogenous cannabinoid and the nitricoxidergic systems interact between them in the modulation of SIA. The ECS exerts a more prominent influence on cold rather than heat SIA. Differences in modulation probably depend on the type of stress, due to the different participation of ECS in the mechanisms of SIA development.
format	article
author	Nocheva H. Sabit Z. Grigorov E.
author_facet	Nocheva H. Sabit Z. Grigorov E.
author_sort	Nocheva H.
title	The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
title_short	The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
title_full	The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
title_fullStr	The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
title_full_unstemmed	The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia
title_sort	endogenous cannabinoid and the nitricoxidergic systems differently influence heat and cold stress-induced analgesia
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/1386bcbd34d348d5aa293314adc89fba
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The Endogenous Cannabinoid and the Nitricoxidergic Systems Differently Influence Heat and Cold Stress-Induced Analgesia

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