Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus

Chenghui Zhang, Suyuan Wang, Mingxia Li, Yunhong Wu Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, People’s Republic of ChinaCorrespondence: Yunhong WuDepartment of Endocrinology and Metabolism,...

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Autores principales:	Zhang C, Wang S, Li M, Wu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	atherosclerosis cardio-ankle vascular index diabetic retinopathy ankle-brachial index carotid plaque Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1388173a7f01481584cdec964a02000a
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spelling	oai:doaj.org-article:1388173a7f01481584cdec964a02000a2021-12-02T10:15:36ZAssociation Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/1388173a7f01481584cdec964a02000a2020-06-01T00:00:00Zhttps://www.dovepress.com/association-between-atherosclerosis-and-diabetic-retinopathy-in-chines-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Chenghui Zhang, Suyuan Wang, Mingxia Li, Yunhong Wu Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, People’s Republic of ChinaCorrespondence: Yunhong WuDepartment of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, No. 20 Ximianqiao Street, Chengdu, Sichuan 610041, People’s Republic of ChinaEmail Wu_yunhong@163.comAim: To explore the association between the atherosclerosis and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: This hospital-based cross-sectional study included 949 patients (700 males and 249 females) with T2DM. The atherosclerotic parameters were assessed using the cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), and carotid plaque. DR was assessed and graded using digital retinal photography and fundus fluorescein angiography as either nonproliferative DR (NPDR) or proliferative DR (PDR). Multiple logistic regression analysis was performed to identify the associations between the atherosclerotic parameters and DR status.Results: The prevalence of DR was 23.6% in total patients, including 167 (17.6%) patients with NPDR and 57 (6.0%) patients with PDR. Patients with NPDR and PDR were more likely to have higher prevalence of increased CAVI, increased ABI, and carotid plaque than those without DR. In multivariable adjusted logistic regression analysis, patients with NPDR showed an odds ratio (OR) of 2.59 [95% confidence interval (CI), 1.61– 4.19] for increased CAVI, 1.99 (0.62– 6.34) for increased ABI, and 1.75 (1.13– 2.71) for carotid plaque. Patients with PDR showed an OR of 7.83 (3.52– 17.41) for increased CAVI, 10.65 (3.33– 34.04) for increased ABI, and 11.40 (2.67– 48.63) for carotid plaque.Conclusion: Both NPDR and PDR were independently associated with increased CAVI and presence of carotid plaque in Chinese patients with T2DM.Keywords: atherosclerosis, cardio-ankle vascular index, diabetic retinopathy, ankle-brachial index, carotid plaqueZhang CWang SLi MWu YDove Medical Pressarticleatherosclerosiscardio-ankle vascular indexdiabetic retinopathyankle-brachial indexcarotid plaqueSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1911-1920 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis cardio-ankle vascular index diabetic retinopathy ankle-brachial index carotid plaque Specialties of internal medicine RC581-951
spellingShingle	atherosclerosis cardio-ankle vascular index diabetic retinopathy ankle-brachial index carotid plaque Specialties of internal medicine RC581-951 Zhang C Wang S Li M Wu Y Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus
description	Chenghui Zhang, Suyuan Wang, Mingxia Li, Yunhong Wu Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, People’s Republic of ChinaCorrespondence: Yunhong WuDepartment of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, No. 20 Ximianqiao Street, Chengdu, Sichuan 610041, People’s Republic of ChinaEmail Wu_yunhong@163.comAim: To explore the association between the atherosclerosis and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: This hospital-based cross-sectional study included 949 patients (700 males and 249 females) with T2DM. The atherosclerotic parameters were assessed using the cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), and carotid plaque. DR was assessed and graded using digital retinal photography and fundus fluorescein angiography as either nonproliferative DR (NPDR) or proliferative DR (PDR). Multiple logistic regression analysis was performed to identify the associations between the atherosclerotic parameters and DR status.Results: The prevalence of DR was 23.6% in total patients, including 167 (17.6%) patients with NPDR and 57 (6.0%) patients with PDR. Patients with NPDR and PDR were more likely to have higher prevalence of increased CAVI, increased ABI, and carotid plaque than those without DR. In multivariable adjusted logistic regression analysis, patients with NPDR showed an odds ratio (OR) of 2.59 [95% confidence interval (CI), 1.61– 4.19] for increased CAVI, 1.99 (0.62– 6.34) for increased ABI, and 1.75 (1.13– 2.71) for carotid plaque. Patients with PDR showed an OR of 7.83 (3.52– 17.41) for increased CAVI, 10.65 (3.33– 34.04) for increased ABI, and 11.40 (2.67– 48.63) for carotid plaque.Conclusion: Both NPDR and PDR were independently associated with increased CAVI and presence of carotid plaque in Chinese patients with T2DM.Keywords: atherosclerosis, cardio-ankle vascular index, diabetic retinopathy, ankle-brachial index, carotid plaque
format	article
author	Zhang C Wang S Li M Wu Y
author_facet	Zhang C Wang S Li M Wu Y
author_sort	Zhang C
title	Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus
title_short	Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus
title_full	Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus
title_fullStr	Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus
title_full_unstemmed	Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus
title_sort	association between atherosclerosis and diabetic retinopathy in chinese patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1388173a7f01481584cdec964a02000a
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_version_	1718397454427095040

Association Between Atherosclerosis and Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus

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