Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models...

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Auteurs principaux:	F. Zhang, N. N. Parayath, C. I. Ene, S. B. Stephan, A. L. Koehne, M. E. Coon, E. C. Holland, M. T. Stephan
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf97
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spelling	oai:doaj.org-article:138b3dd54491408c818b9a2f0d6eaf972021-12-02T17:02:19ZGenetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers10.1038/s41467-019-11911-52041-1723https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf972019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11911-5https://doaj.org/toc/2041-1723The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.F. ZhangN. N. ParayathC. I. EneS. B. StephanA. L. KoehneM. E. CoonE. C. HollandM. T. StephanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q F. Zhang N. N. Parayath C. I. Ene S. B. Stephan A. L. Koehne M. E. Coon E. C. Holland M. T. Stephan Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
description	The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.
format	article
author	F. Zhang N. N. Parayath C. I. Ene S. B. Stephan A. L. Koehne M. E. Coon E. C. Holland M. T. Stephan
author_facet	F. Zhang N. N. Parayath C. I. Ene S. B. Stephan A. L. Koehne M. E. Coon E. C. Holland M. T. Stephan
author_sort	F. Zhang
title	Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_short	Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_full	Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_fullStr	Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_full_unstemmed	Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_sort	genetic programming of macrophages to perform anti-tumor functions using targeted mrna nanocarriers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf97
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Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

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