Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models...

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Autores principales: F. Zhang, N. N. Parayath, C. I. Ene, S. B. Stephan, A. L. Koehne, M. E. Coon, E. C. Holland, M. T. Stephan
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Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf97
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spelling oai:doaj.org-article:138b3dd54491408c818b9a2f0d6eaf972021-12-02T17:02:19ZGenetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers10.1038/s41467-019-11911-52041-1723https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf972019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11911-5https://doaj.org/toc/2041-1723The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.F. ZhangN. N. ParayathC. I. EneS. B. StephanA. L. KoehneM. E. CoonE. C. HollandM. T. StephanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
F. Zhang
N. N. Parayath
C. I. Ene
S. B. Stephan
A. L. Koehne
M. E. Coon
E. C. Holland
M. T. Stephan
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
description The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.
format article
author F. Zhang
N. N. Parayath
C. I. Ene
S. B. Stephan
A. L. Koehne
M. E. Coon
E. C. Holland
M. T. Stephan
author_facet F. Zhang
N. N. Parayath
C. I. Ene
S. B. Stephan
A. L. Koehne
M. E. Coon
E. C. Holland
M. T. Stephan
author_sort F. Zhang
title Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_short Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_full Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_fullStr Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_full_unstemmed Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
title_sort genetic programming of macrophages to perform anti-tumor functions using targeted mrna nanocarriers
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/138b3dd54491408c818b9a2f0d6eaf97
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