Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

Dentate gyrus (DG) is critical for memory formation in the hippocampus but its role in memory retrieval is unclear. Here, Gross and colleagues, show that granule cells in DG are not required for memory retrieval but for maintenance, and inhibiting them with a drug leads to rapid loss of memory.

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Autores principales:	Noelia Madroñal, José M. Delgado-García, Azahara Fernández-Guizán, Jayanta Chatterjee, Maja Köhn, Camilla Mattucci, Apar Jain, Theodoros Tsetsenis, Anna Illarionova, Valery Grinevich, Cornelius T. Gross, Agnès Gruart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13901a51755d460bbbcc7c6b45385d81
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spelling	oai:doaj.org-article:13901a51755d460bbbcc7c6b45385d812021-12-02T15:35:19ZRapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells10.1038/ncomms109232041-1723https://doaj.org/article/13901a51755d460bbbcc7c6b45385d812016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10923https://doaj.org/toc/2041-1723Dentate gyrus (DG) is critical for memory formation in the hippocampus but its role in memory retrieval is unclear. Here, Gross and colleagues, show that granule cells in DG are not required for memory retrieval but for maintenance, and inhibiting them with a drug leads to rapid loss of memory.Noelia MadroñalJosé M. Delgado-GarcíaAzahara Fernández-GuizánJayanta ChatterjeeMaja KöhnCamilla MattucciApar JainTheodoros TsetsenisAnna IllarionovaValery GrinevichCornelius T. GrossAgnès GruartNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noelia Madroñal José M. Delgado-García Azahara Fernández-Guizán Jayanta Chatterjee Maja Köhn Camilla Mattucci Apar Jain Theodoros Tsetsenis Anna Illarionova Valery Grinevich Cornelius T. Gross Agnès Gruart Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
description	Dentate gyrus (DG) is critical for memory formation in the hippocampus but its role in memory retrieval is unclear. Here, Gross and colleagues, show that granule cells in DG are not required for memory retrieval but for maintenance, and inhibiting them with a drug leads to rapid loss of memory.
format	article
author	Noelia Madroñal José M. Delgado-García Azahara Fernández-Guizán Jayanta Chatterjee Maja Köhn Camilla Mattucci Apar Jain Theodoros Tsetsenis Anna Illarionova Valery Grinevich Cornelius T. Gross Agnès Gruart
author_facet	Noelia Madroñal José M. Delgado-García Azahara Fernández-Guizán Jayanta Chatterjee Maja Köhn Camilla Mattucci Apar Jain Theodoros Tsetsenis Anna Illarionova Valery Grinevich Cornelius T. Gross Agnès Gruart
author_sort	Noelia Madroñal
title	Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
title_short	Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
title_full	Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
title_fullStr	Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
title_full_unstemmed	Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
title_sort	rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/13901a51755d460bbbcc7c6b45385d81
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Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

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