Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors

Michael De Santis,1,2 Xu-Feng Huang,2 Chao Deng1,2 1Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia; 2School of Medicine, University of Wollongong, Wollongong, NSW, Australia Background: Antipsychotic drug (AP...

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Autores principales:	De Santis M, Huang XF, Deng C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Antipsychotic drug serotonin risperidone olanzapine aripiprazole development juvenile Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1394b8f76be14cffa5c49804ddbfc6b3
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spelling	oai:doaj.org-article:1394b8f76be14cffa5c49804ddbfc6b32021-12-02T04:24:38ZEarly antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors1178-2021https://doaj.org/article/1394b8f76be14cffa5c49804ddbfc6b32018-06-01T00:00:00Zhttps://www.dovepress.com/early-antipsychotic-treatment-in-juvenile-rats-elicits-long-term-alter-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Michael De Santis,1,2 Xu-Feng Huang,2 Chao Deng1,2 1Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia; 2School of Medicine, University of Wollongong, Wollongong, NSW, Australia Background: Antipsychotic drug (APD) prescription/use in children has increased significantly worldwide, despite limited insight into potential long-term effects of treatment on adult brain functioning. While initial long-term studies have uncovered alterations to behaviors following early APD treatment, further investigations into potential changes to receptor density levels of related neurotransmitter (NT) systems are required. Methods: The current investigation utilized an animal model for early APD treatment with aripiprazole, olanzapine, and risperidone in male and female juvenile rats to investigate potential long-term changes to the adult serotonin (5-HT) NT system. Levels of 5-HT1A, 5-HT2A, and 5-HT2C receptors were measured in the prefrontal cortex (PFC), caudate putamen (CPu), nucleus accumbens (NAc), and hippocampus via Western Blot and receptor autoradiography. Results: In the male cohort, long-term changes to 5-HT2A and 5-HT2C receptors were found mostly across hippocampal and cortical brain regions following early aripiprazole and olanzapine treatment, while early risperidone treatment changed 5-HT1A receptor levels in the NAc and PFC. Lesser effects were uncovered in the female cohort with aripiprazole, olanzapine and risperidone to alter 5-HT1A and 5-HT2A receptors in NAc and hippocampal brain regions, respectively. Conclusion: The results of this study suggest that early treatment of various APDs in juvenile rats may cause gender and brain regional specific changes in 5-HT2A and 5-HT2C receptors in the adult brain. Keywords: antipsychotic drug, serotonin, risperidone, olanzapine, aripiprazole, development, juvenileDe Santis MHuang XFDeng CDove Medical PressarticleAntipsychotic drugserotoninrisperidoneolanzapinearipiprazoledevelopmentjuvenileNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1569-1583 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antipsychotic drug serotonin risperidone olanzapine aripiprazole development juvenile Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Antipsychotic drug serotonin risperidone olanzapine aripiprazole development juvenile Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 De Santis M Huang XF Deng C Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
description	Michael De Santis,1,2 Xu-Feng Huang,2 Chao Deng1,2 1Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia; 2School of Medicine, University of Wollongong, Wollongong, NSW, Australia Background: Antipsychotic drug (APD) prescription/use in children has increased significantly worldwide, despite limited insight into potential long-term effects of treatment on adult brain functioning. While initial long-term studies have uncovered alterations to behaviors following early APD treatment, further investigations into potential changes to receptor density levels of related neurotransmitter (NT) systems are required. Methods: The current investigation utilized an animal model for early APD treatment with aripiprazole, olanzapine, and risperidone in male and female juvenile rats to investigate potential long-term changes to the adult serotonin (5-HT) NT system. Levels of 5-HT1A, 5-HT2A, and 5-HT2C receptors were measured in the prefrontal cortex (PFC), caudate putamen (CPu), nucleus accumbens (NAc), and hippocampus via Western Blot and receptor autoradiography. Results: In the male cohort, long-term changes to 5-HT2A and 5-HT2C receptors were found mostly across hippocampal and cortical brain regions following early aripiprazole and olanzapine treatment, while early risperidone treatment changed 5-HT1A receptor levels in the NAc and PFC. Lesser effects were uncovered in the female cohort with aripiprazole, olanzapine and risperidone to alter 5-HT1A and 5-HT2A receptors in NAc and hippocampal brain regions, respectively. Conclusion: The results of this study suggest that early treatment of various APDs in juvenile rats may cause gender and brain regional specific changes in 5-HT2A and 5-HT2C receptors in the adult brain. Keywords: antipsychotic drug, serotonin, risperidone, olanzapine, aripiprazole, development, juvenile
format	article
author	De Santis M Huang XF Deng C
author_facet	De Santis M Huang XF Deng C
author_sort	De Santis M
title	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
title_short	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
title_full	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
title_fullStr	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
title_full_unstemmed	Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
title_sort	early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1394b8f76be14cffa5c49804ddbfc6b3
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Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors

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