Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants

Background: Recently, the D-dimer biomarker has gained the researchers' attention for predicting infections. We aimed to determine the relationship between this marker and other inflammatory markers involved in orthopedic implant-associated infections. Materials and Methods: In this study, all...

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Autores principales:	Adel Ebrahimpour, Mohammad Ali Okhovatpour, Ali Tabrizi, Mahsa Bakhshmandi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	c-reactive protein d-dimer erythrocyte sedimentation rate infection orthopedic osteomyelitis Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1399c37bc6df4eaf8e608792552567bd
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spelling	oai:doaj.org-article:1399c37bc6df4eaf8e608792552567bd2021-11-12T10:03:58ZValue of D-dimer as a diagnostic marker of infection associated with orthopedic implants2277-917510.4103/abr.abr_277_20https://doaj.org/article/1399c37bc6df4eaf8e608792552567bd2021-01-01T00:00:00Zhttp://www.advbiores.net/article.asp?issn=2277-9175;year=2021;volume=10;issue=1;spage=28;epage=28;aulast=Ebrahimpourhttps://doaj.org/toc/2277-9175Background: Recently, the D-dimer biomarker has gained the researchers' attention for predicting infections. We aimed to determine the relationship between this marker and other inflammatory markers involved in orthopedic implant-associated infections. Materials and Methods: In this study, all patients diagnosed with an orthopedic implant-associated infection were investigated in 3 years. The serum level of D-dimer, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) was measured. Infection was diagnosed based on the clinical and culture results of biopsy samples. Results: The cultured microorganisms, detected in 26 patients with infections, included Staphylococcus aureus (n = 13, 50%), Staphylococcus epidermidis (n = 2, 7.7%), Klebsiella aerogenes (n = 8, 30.8%), and Pseudomonas aeruginosa (n = 3, 11. 5%). Based on laboratory findings, there was a significant difference in the CRP level and ESR (P = 0.001). Although the level of D-dimer was higher in infected patients, compared to the controls (992.6 ± 667.2 vs. 690.1 ± 250.2 ng/mL), the difference was not statistically significant. There was no significant correlation between the elevated D-dimer level and CRP level, whereas ESR had a positive correlation with the elevated D-dimer level (r = 0.6, P = 0.03). The sensitivity, specificity, and positive predictive value (PPV) of D-dimer in the prediction of infection were 65%, 57%, and 45%, respectively. Furthermore, the sensitivity, specificity, and PPV of CRP were 100%, 92.3%, and 95%, respectively, whereas the corresponding values for ESR were 85%, 69.2%, and 62%, respectively. Conclusion: Measurement of the serum D-dimer level is not efficient for the diagnosis of orthopedic implant-associated infections due to its low predictive value. Furthermore, there was no significant correlation between the serum D-dimer level and CRP.Adel EbrahimpourMohammad Ali OkhovatpourAli TabriziMahsa BakhshmandiWolters Kluwer Medknow Publicationsarticle c-reactive proteind-dimererythrocyte sedimentation rateinfectionorthopedicosteomyelitis MedicineRBiology (General)QH301-705.5ENAdvanced Biomedical Research, Vol 10, Iss 1, Pp 28-28 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	c-reactive protein d-dimer erythrocyte sedimentation rate infection orthopedic osteomyelitis Medicine R Biology (General) QH301-705.5
spellingShingle	c-reactive protein d-dimer erythrocyte sedimentation rate infection orthopedic osteomyelitis Medicine R Biology (General) QH301-705.5 Adel Ebrahimpour Mohammad Ali Okhovatpour Ali Tabrizi Mahsa Bakhshmandi Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
description	Background: Recently, the D-dimer biomarker has gained the researchers' attention for predicting infections. We aimed to determine the relationship between this marker and other inflammatory markers involved in orthopedic implant-associated infections. Materials and Methods: In this study, all patients diagnosed with an orthopedic implant-associated infection were investigated in 3 years. The serum level of D-dimer, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) was measured. Infection was diagnosed based on the clinical and culture results of biopsy samples. Results: The cultured microorganisms, detected in 26 patients with infections, included Staphylococcus aureus (n = 13, 50%), Staphylococcus epidermidis (n = 2, 7.7%), Klebsiella aerogenes (n = 8, 30.8%), and Pseudomonas aeruginosa (n = 3, 11. 5%). Based on laboratory findings, there was a significant difference in the CRP level and ESR (P = 0.001). Although the level of D-dimer was higher in infected patients, compared to the controls (992.6 ± 667.2 vs. 690.1 ± 250.2 ng/mL), the difference was not statistically significant. There was no significant correlation between the elevated D-dimer level and CRP level, whereas ESR had a positive correlation with the elevated D-dimer level (r = 0.6, P = 0.03). The sensitivity, specificity, and positive predictive value (PPV) of D-dimer in the prediction of infection were 65%, 57%, and 45%, respectively. Furthermore, the sensitivity, specificity, and PPV of CRP were 100%, 92.3%, and 95%, respectively, whereas the corresponding values for ESR were 85%, 69.2%, and 62%, respectively. Conclusion: Measurement of the serum D-dimer level is not efficient for the diagnosis of orthopedic implant-associated infections due to its low predictive value. Furthermore, there was no significant correlation between the serum D-dimer level and CRP.
format	article
author	Adel Ebrahimpour Mohammad Ali Okhovatpour Ali Tabrizi Mahsa Bakhshmandi
author_facet	Adel Ebrahimpour Mohammad Ali Okhovatpour Ali Tabrizi Mahsa Bakhshmandi
author_sort	Adel Ebrahimpour
title	Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
title_short	Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
title_full	Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
title_fullStr	Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
title_full_unstemmed	Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
title_sort	value of d-dimer as a diagnostic marker of infection associated with orthopedic implants
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/1399c37bc6df4eaf8e608792552567bd
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Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants

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