Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins for multidimensional control of functional activi...

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Autores principales:	Dirk A. Kleinjan, Caroline Wardrope, Si Nga Sou, Susan J. Rosser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/139a8430e48d45c080b0de7895062ab0
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spelling	oai:doaj.org-article:139a8430e48d45c080b0de7895062ab02021-12-02T14:40:59ZDrug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors10.1038/s41467-017-01222-y2041-1723https://doaj.org/article/139a8430e48d45c080b0de7895062ab02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01222-yhttps://doaj.org/toc/2041-1723Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins for multidimensional control of functional activity.Dirk A. KleinjanCaroline WardropeSi Nga SouSusan J. RosserNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dirk A. Kleinjan Caroline Wardrope Si Nga Sou Susan J. Rosser Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
description	Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins for multidimensional control of functional activity.
format	article
author	Dirk A. Kleinjan Caroline Wardrope Si Nga Sou Susan J. Rosser
author_facet	Dirk A. Kleinjan Caroline Wardrope Si Nga Sou Susan J. Rosser
author_sort	Dirk A. Kleinjan
title	Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
title_short	Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
title_full	Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
title_fullStr	Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
title_full_unstemmed	Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
title_sort	drug-tunable multidimensional synthetic gene control using inducible degron-tagged dcas9 effectors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/139a8430e48d45c080b0de7895062ab0
work_keys_str_mv	AT dirkakleinjan drugtunablemultidimensionalsyntheticgenecontrolusinginducibledegrontaggeddcas9effectors AT carolinewardrope drugtunablemultidimensionalsyntheticgenecontrolusinginducibledegrontaggeddcas9effectors AT singasou drugtunablemultidimensionalsyntheticgenecontrolusinginducibledegrontaggeddcas9effectors AT susanjrosser drugtunablemultidimensionalsyntheticgenecontrolusinginducibledegrontaggeddcas9effectors
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Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

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