Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event

Laurine Robert,1 Grégoire Ficheur,2 Sophie Gautier,3 Alexandre Servais,1 Michel Luyckx,4 Julien Soula,1 Bertrand Decaudin,5 François Glowacki,6 François Puisieux,1 Emmanuel Chazard,2 Jean-Baptiste Beuscart1 1Univ. Lille, CHU Lille, EA2694, Lille, F-59000, France; 2Un...

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Autores principales:	Robert L, Ficheur G, Gautier S, Servais A, Luyckx M, Soula J, Decaudin B, Glowacki F, Puisieux F, Chazard E, Beuscart JB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	adverse drug reactions elderly prevention acute kidney injury Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/139b10c253d340a59d5fa9aa4963b4fb
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spelling	oai:doaj.org-article:139b10c253d340a59d5fa9aa4963b4fb2021-12-02T09:48:56ZCommunity-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event1178-1998https://doaj.org/article/139b10c253d340a59d5fa9aa4963b4fb2019-12-01T00:00:00Zhttps://www.dovepress.com/community-acquired-acute-kidney-injury-induced-by-drugs-in-older-patie-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Laurine Robert,1 Grégoire Ficheur,2 Sophie Gautier,3 Alexandre Servais,1 Michel Luyckx,4 Julien Soula,1 Bertrand Decaudin,5 François Glowacki,6 François Puisieux,1 Emmanuel Chazard,2 Jean-Baptiste Beuscart1 1Univ. Lille, CHU Lille, EA2694, Lille, F-59000, France; 2Univ. Lille, CHU Lille, EA2694, Public Health Department, Lille, F-59000, France; 3Univ. Lille, CHU Lille, UMR 1171, Department of Pharmacology, Lille, F-59000, France; 4Univ. Lille, EA7365, F-59000 Lille, CH Denain, Department of Pharmacy, Denain, F-59220, France; 5Univ. Lille, CHU Lille, EA7365, Department of Pharmacy, Lille, F-59000, France; 6Univ. Lille, CHU Lille, EA4483 IMPECS, Department of Nephrology, Lille, F-59000, FranceCorrespondence: Laurine RobertCERIM – EA 2694, Faculté de Médecine - Pôle Recherche, 1 Place de Verdun, Lille Cedex 59045 FranceEmail laurine.robert.etu@univ-lille.frPurpose: Community-acquired acute kidney injury (CA-AKI) is a frequent and severe adverse drug reaction (ADR) among older patients. The combination of drugs and other CA-AKI risk factors was barely evaluated. The objectives of our study were to both accurately identify CA-AKI induced by drugs in older patients, and to describe their combination with other risk factors.Patients and methods: We conducted a retrospective, single-center study in a general hospital over a two-year period. An automated detection identified CA-AKI according to KDIGO criteria, amongst 4,767 eligible inpatient stays among patients aged 75 years or older. Two independent experts reviewed all CA-AKI events to adjudicate drug involvement (Naranjo scale), identify inappropriate prescriptions (STOPP criteria), evaluate avoidability (Hallas criteria) and identify combined risk factors.Results: An expert review confirmed 713 CA-AKI (15.0% of inpatient stays) and determined that 419 (58.8%) CA-AKI were induced by drugs. A multifactorial cause (i.e., at least one drug with a precipitating factor) was found in 63.2% of drug-induced CA-AKI. Most of the drug-induced events were avoidable (66.8%), mainly in relation to a multifactorial cause.Conclusion: Drug-induced CA-AKI were frequent, multifactorial events in hospitalized older patients and their prevention should focus on combinations with precipitating factors.Keywords: adverse drug reactions, elderly, prevention, acute kidney injuryRobert LFicheur GGautier SServais ALuyckx MSoula JDecaudin BGlowacki FPuisieux FChazard EBeuscart JBDove Medical Pressarticleadverse drug reactionselderlypreventionacute kidney injuryGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 2105-2113 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse drug reactions elderly prevention acute kidney injury Geriatrics RC952-954.6
spellingShingle	adverse drug reactions elderly prevention acute kidney injury Geriatrics RC952-954.6 Robert L Ficheur G Gautier S Servais A Luyckx M Soula J Decaudin B Glowacki F Puisieux F Chazard E Beuscart JB Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event
description	Laurine Robert,1 Grégoire Ficheur,2 Sophie Gautier,3 Alexandre Servais,1 Michel Luyckx,4 Julien Soula,1 Bertrand Decaudin,5 François Glowacki,6 François Puisieux,1 Emmanuel Chazard,2 Jean-Baptiste Beuscart1 1Univ. Lille, CHU Lille, EA2694, Lille, F-59000, France; 2Univ. Lille, CHU Lille, EA2694, Public Health Department, Lille, F-59000, France; 3Univ. Lille, CHU Lille, UMR 1171, Department of Pharmacology, Lille, F-59000, France; 4Univ. Lille, EA7365, F-59000 Lille, CH Denain, Department of Pharmacy, Denain, F-59220, France; 5Univ. Lille, CHU Lille, EA7365, Department of Pharmacy, Lille, F-59000, France; 6Univ. Lille, CHU Lille, EA4483 IMPECS, Department of Nephrology, Lille, F-59000, FranceCorrespondence: Laurine RobertCERIM – EA 2694, Faculté de Médecine - Pôle Recherche, 1 Place de Verdun, Lille Cedex 59045 FranceEmail laurine.robert.etu@univ-lille.frPurpose: Community-acquired acute kidney injury (CA-AKI) is a frequent and severe adverse drug reaction (ADR) among older patients. The combination of drugs and other CA-AKI risk factors was barely evaluated. The objectives of our study were to both accurately identify CA-AKI induced by drugs in older patients, and to describe their combination with other risk factors.Patients and methods: We conducted a retrospective, single-center study in a general hospital over a two-year period. An automated detection identified CA-AKI according to KDIGO criteria, amongst 4,767 eligible inpatient stays among patients aged 75 years or older. Two independent experts reviewed all CA-AKI events to adjudicate drug involvement (Naranjo scale), identify inappropriate prescriptions (STOPP criteria), evaluate avoidability (Hallas criteria) and identify combined risk factors.Results: An expert review confirmed 713 CA-AKI (15.0% of inpatient stays) and determined that 419 (58.8%) CA-AKI were induced by drugs. A multifactorial cause (i.e., at least one drug with a precipitating factor) was found in 63.2% of drug-induced CA-AKI. Most of the drug-induced events were avoidable (66.8%), mainly in relation to a multifactorial cause.Conclusion: Drug-induced CA-AKI were frequent, multifactorial events in hospitalized older patients and their prevention should focus on combinations with precipitating factors.Keywords: adverse drug reactions, elderly, prevention, acute kidney injury
format	article
author	Robert L Ficheur G Gautier S Servais A Luyckx M Soula J Decaudin B Glowacki F Puisieux F Chazard E Beuscart JB
author_facet	Robert L Ficheur G Gautier S Servais A Luyckx M Soula J Decaudin B Glowacki F Puisieux F Chazard E Beuscart JB
author_sort	Robert L
title	Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event
title_short	Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event
title_full	Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event
title_fullStr	Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event
title_full_unstemmed	Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event
title_sort	community-acquired acute kidney injury induced by drugs in older patients: a multifactorial event
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/139b10c253d340a59d5fa9aa4963b4fb
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Community-Acquired Acute Kidney Injury Induced By Drugs In Older Patients: A Multifactorial Event

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