Roles of mesenchymal stromal cells in the head and neck cancer microenvironment

Head and neck cancer (HNC), a common malignancy worldwide, is associated with high morbidity and mortality rates. Squamous cell carcinoma is the most common HNC type, followed by salivary gland carcinomas, head and neck sarcomas, and lymphomas. The microenvironment of HNCs comprises various cells th...

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Autores principales:	Marcelo Coutinho de Miranda, Mariane Izabella Abreu de Melo, Pricila da Silva Cunha, Jovino Gentilini, Júnior, Jerusa Araújo Quintão Arantes Faria, Michele Angela Rodrigues, Dawidson Assis Gomes
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cancer microenvironment Mesenchymal stromal cells Head and neck cancer Squamous cell carcinoma Cancer metastasis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/13a553e068fc470b9fb28553041a028a
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spelling	oai:doaj.org-article:13a553e068fc470b9fb28553041a028a2021-11-14T04:29:04ZRoles of mesenchymal stromal cells in the head and neck cancer microenvironment0753-332210.1016/j.biopha.2021.112269https://doaj.org/article/13a553e068fc470b9fb28553041a028a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010532https://doaj.org/toc/0753-3322Head and neck cancer (HNC), a common malignancy worldwide, is associated with high morbidity and mortality rates. Squamous cell carcinoma is the most common HNC type, followed by salivary gland carcinomas, head and neck sarcomas, and lymphomas. The microenvironment of HNCs comprises various cells that regulate tumor development. Recent studies have reported that the tumor microenvironment, which modulates cancer progression, regulates cancer treatment response. However, the presence of different types of stromal cells in cancers is a major challenge to elucidate the role of individual cells in tumor progression. The role of mesenchymal stromal cells (MSCs), which are a component of the tumor microenvironment, in HNC is unclear. The major impediment for characterizing the role of MSCs in cancer progression is the lack of MSC-specific markers and their phenotypic similarity with stromal cells. This review aimed to summarize the latest findings on the role of MSCs in the progression of HNC to improve our understanding of HNC pathophysiology.Marcelo Coutinho de MirandaMariane Izabella Abreu de MeloPricila da Silva CunhaJovino Gentilini, JúniorJerusa Araújo Quintão Arantes FariaMichele Angela RodriguesDawidson Assis GomesElsevierarticleCancer microenvironmentMesenchymal stromal cellsHead and neck cancerSquamous cell carcinomaCancer metastasisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112269- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer microenvironment Mesenchymal stromal cells Head and neck cancer Squamous cell carcinoma Cancer metastasis Therapeutics. Pharmacology RM1-950
spellingShingle	Cancer microenvironment Mesenchymal stromal cells Head and neck cancer Squamous cell carcinoma Cancer metastasis Therapeutics. Pharmacology RM1-950 Marcelo Coutinho de Miranda Mariane Izabella Abreu de Melo Pricila da Silva Cunha Jovino Gentilini, Júnior Jerusa Araújo Quintão Arantes Faria Michele Angela Rodrigues Dawidson Assis Gomes Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
description	Head and neck cancer (HNC), a common malignancy worldwide, is associated with high morbidity and mortality rates. Squamous cell carcinoma is the most common HNC type, followed by salivary gland carcinomas, head and neck sarcomas, and lymphomas. The microenvironment of HNCs comprises various cells that regulate tumor development. Recent studies have reported that the tumor microenvironment, which modulates cancer progression, regulates cancer treatment response. However, the presence of different types of stromal cells in cancers is a major challenge to elucidate the role of individual cells in tumor progression. The role of mesenchymal stromal cells (MSCs), which are a component of the tumor microenvironment, in HNC is unclear. The major impediment for characterizing the role of MSCs in cancer progression is the lack of MSC-specific markers and their phenotypic similarity with stromal cells. This review aimed to summarize the latest findings on the role of MSCs in the progression of HNC to improve our understanding of HNC pathophysiology.
format	article
author	Marcelo Coutinho de Miranda Mariane Izabella Abreu de Melo Pricila da Silva Cunha Jovino Gentilini, Júnior Jerusa Araújo Quintão Arantes Faria Michele Angela Rodrigues Dawidson Assis Gomes
author_facet	Marcelo Coutinho de Miranda Mariane Izabella Abreu de Melo Pricila da Silva Cunha Jovino Gentilini, Júnior Jerusa Araújo Quintão Arantes Faria Michele Angela Rodrigues Dawidson Assis Gomes
author_sort	Marcelo Coutinho de Miranda
title	Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
title_short	Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
title_full	Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
title_fullStr	Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
title_full_unstemmed	Roles of mesenchymal stromal cells in the head and neck cancer microenvironment
title_sort	roles of mesenchymal stromal cells in the head and neck cancer microenvironment
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/13a553e068fc470b9fb28553041a028a
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Roles of mesenchymal stromal cells in the head and neck cancer microenvironment

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