Sexually antagonistic selection in human male homosexuality.

Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furt...

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Autores principales:	Andrea Camperio Ciani, Paolo Cermelli, Giovanni Zanzotto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13af2a83c5114aeba71ccac2cf0ac9a0
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spelling	oai:doaj.org-article:13af2a83c5114aeba71ccac2cf0ac9a02021-11-25T06:12:01ZSexually antagonistic selection in human male homosexuality.1932-620310.1371/journal.pone.0002282https://doaj.org/article/13af2a83c5114aeba71ccac2cf0ac9a02008-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18560521/?tool=EBIhttps://doaj.org/toc/1932-6203Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of hypotheses have attempted to give an evolutionary explanation for the long-standing persistence of this trait, and for its asymmetric distribution in family lines; however a satisfactory understanding of the population genetics of male homosexuality is lacking at present. We perform a systematic mathematical analysis of the propagation and equilibrium of the putative genetic factors for male homosexuality in the population, based on the selection equation for one or two diallelic loci and Bayesian statistics for pedigree investigation. We show that only the two-locus genetic model with at least one locus on the X chromosome, and in which gene expression is sexually antagonistic (increasing female fitness but decreasing male fitness), accounts for all known empirical data. Our results help clarify the basic evolutionary dynamics of male homosexuality, establishing this as a clearly ascertained sexually antagonistic human trait.Andrea Camperio CianiPaolo CermelliGiovanni ZanzottoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 6, p e2282 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Camperio Ciani Paolo Cermelli Giovanni Zanzotto Sexually antagonistic selection in human male homosexuality.
description	Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of hypotheses have attempted to give an evolutionary explanation for the long-standing persistence of this trait, and for its asymmetric distribution in family lines; however a satisfactory understanding of the population genetics of male homosexuality is lacking at present. We perform a systematic mathematical analysis of the propagation and equilibrium of the putative genetic factors for male homosexuality in the population, based on the selection equation for one or two diallelic loci and Bayesian statistics for pedigree investigation. We show that only the two-locus genetic model with at least one locus on the X chromosome, and in which gene expression is sexually antagonistic (increasing female fitness but decreasing male fitness), accounts for all known empirical data. Our results help clarify the basic evolutionary dynamics of male homosexuality, establishing this as a clearly ascertained sexually antagonistic human trait.
format	article
author	Andrea Camperio Ciani Paolo Cermelli Giovanni Zanzotto
author_facet	Andrea Camperio Ciani Paolo Cermelli Giovanni Zanzotto
author_sort	Andrea Camperio Ciani
title	Sexually antagonistic selection in human male homosexuality.
title_short	Sexually antagonistic selection in human male homosexuality.
title_full	Sexually antagonistic selection in human male homosexuality.
title_fullStr	Sexually antagonistic selection in human male homosexuality.
title_full_unstemmed	Sexually antagonistic selection in human male homosexuality.
title_sort	sexually antagonistic selection in human male homosexuality.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/13af2a83c5114aeba71ccac2cf0ac9a0
work_keys_str_mv	AT andreacamperiociani sexuallyantagonisticselectioninhumanmalehomosexuality AT paolocermelli sexuallyantagonisticselectioninhumanmalehomosexuality AT giovannizanzotto sexuallyantagonisticselectioninhumanmalehomosexuality
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Sexually antagonistic selection in human male homosexuality.

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