Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers

Thiram causes tibial dyschondroplasia in broilers, leading to a significant economic loss in the poultry industry. Our study explored the effects of taurine in thiram induced tibial dyschondroplasia (TD) through in vivo and in vitro approches. In in vivo study, thiram resulted in lameness disorder,...

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Autores principales:	Yanmei Ding, Wangyuan Yao, Muhammad Fakhar-e-Alam Kulyar, Quan Mo, Huachun Pan, Yan Zhang, Bingjie Ma, Ya He, Mengdi Zhang, Jiajia Hong, Muhammad Waqas, Jiakui Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	TD Chondrocytes Thiram Taurine Pesticides HIF-1α/VEGFA Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/13baac88754a41dbb03bca6f74c071d6
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spelling	oai:doaj.org-article:13baac88754a41dbb03bca6f74c071d62021-11-14T04:28:24ZTaurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers0147-651310.1016/j.ecoenv.2021.112981https://doaj.org/article/13baac88754a41dbb03bca6f74c071d62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010939https://doaj.org/toc/0147-6513Thiram causes tibial dyschondroplasia in broilers, leading to a significant economic loss in the poultry industry. Our study explored the effects of taurine in thiram induced tibial dyschondroplasia (TD) through in vivo and in vitro approches. In in vivo study, thiram resulted in lameness disorder, low production parameters ALP, ACP, and a high level of NOS. While, the taurine exhibited promising effect by reducing lameness, increasing ALP, ACP levels, and significantly lowering NOS level with the restoration of the growth plate. In vitro study, thiram caused distortion and disintegration of chondrocytes. The CCK-8 technique revealed the lower cell activity in TD as compared with the treatment group. Even, the treatment and taurine groups had higher cell activity than control group. Also, the chondrocyte morphology progressively reverted to normal after taurine treatment. It might effectively decrease the symptoms of TD in broilers and their production performance. Further research found that the taurine effectively improved chondrocytes' cell viability and recovered lameness disorder by regulation of HIF-1α, VEGFA, and Wnt/β-catenin signaling pathways. In summary, these results indicate that taurine has a protective effect on thiram-induced broilers and it can enhance the growth activity by directly affecting the development of chondrocytes and blood vessels.Yanmei DingWangyuan YaoMuhammad Fakhar-e-Alam KulyarQuan MoHuachun PanYan ZhangBingjie MaYa HeMengdi ZhangJiajia HongMuhammad WaqasJiakui LiElsevierarticleTDChondrocytesThiramTaurinePesticidesHIF-1α/VEGFAEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112981- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TD Chondrocytes Thiram Taurine Pesticides HIF-1α/VEGFA Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	TD Chondrocytes Thiram Taurine Pesticides HIF-1α/VEGFA Environmental pollution TD172-193.5 Environmental sciences GE1-350 Yanmei Ding Wangyuan Yao Muhammad Fakhar-e-Alam Kulyar Quan Mo Huachun Pan Yan Zhang Bingjie Ma Ya He Mengdi Zhang Jiajia Hong Muhammad Waqas Jiakui Li Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers
description	Thiram causes tibial dyschondroplasia in broilers, leading to a significant economic loss in the poultry industry. Our study explored the effects of taurine in thiram induced tibial dyschondroplasia (TD) through in vivo and in vitro approches. In in vivo study, thiram resulted in lameness disorder, low production parameters ALP, ACP, and a high level of NOS. While, the taurine exhibited promising effect by reducing lameness, increasing ALP, ACP levels, and significantly lowering NOS level with the restoration of the growth plate. In vitro study, thiram caused distortion and disintegration of chondrocytes. The CCK-8 technique revealed the lower cell activity in TD as compared with the treatment group. Even, the treatment and taurine groups had higher cell activity than control group. Also, the chondrocyte morphology progressively reverted to normal after taurine treatment. It might effectively decrease the symptoms of TD in broilers and their production performance. Further research found that the taurine effectively improved chondrocytes' cell viability and recovered lameness disorder by regulation of HIF-1α, VEGFA, and Wnt/β-catenin signaling pathways. In summary, these results indicate that taurine has a protective effect on thiram-induced broilers and it can enhance the growth activity by directly affecting the development of chondrocytes and blood vessels.
format	article
author	Yanmei Ding Wangyuan Yao Muhammad Fakhar-e-Alam Kulyar Quan Mo Huachun Pan Yan Zhang Bingjie Ma Ya He Mengdi Zhang Jiajia Hong Muhammad Waqas Jiakui Li
author_facet	Yanmei Ding Wangyuan Yao Muhammad Fakhar-e-Alam Kulyar Quan Mo Huachun Pan Yan Zhang Bingjie Ma Ya He Mengdi Zhang Jiajia Hong Muhammad Waqas Jiakui Li
author_sort	Yanmei Ding
title	Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers
title_short	Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers
title_full	Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers
title_fullStr	Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers
title_full_unstemmed	Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers
title_sort	taurine is an effective therapy against thiram induced tibial dyschondroplasia via hif-1α/vegfa and β-catenin/ gsk-3β pathways in broilers
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/13baac88754a41dbb03bca6f74c071d6
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Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers

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