CAR-T and other adoptive cell therapies for B cell malignancies

B cell malignancies pose challenges due to therapeutic resistance and repeated relapse. Advances in adoptive cellular therapies including chimeric antigen receptor (CAR)-T cells have the potential to transform the treatment landscape in hematological and solid tumor cancers. Improvements in construc...

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Autores principales:	Peihua Lu, Holly A. Hill, Lucy J. Navsaria, Michael L. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Chimeric antigen receptor Adoptive cell therapy B cell malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/13baf7e057a4433f9f07fc68916d37eb
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spelling	oai:doaj.org-article:13baf7e057a4433f9f07fc68916d37eb2021-12-01T05:06:47ZCAR-T and other adoptive cell therapies for B cell malignancies2667-005410.1016/j.jncc.2021.07.001https://doaj.org/article/13baf7e057a4433f9f07fc68916d37eb2021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667005421000302https://doaj.org/toc/2667-0054B cell malignancies pose challenges due to therapeutic resistance and repeated relapse. Advances in adoptive cellular therapies including chimeric antigen receptor (CAR)-T cells have the potential to transform the treatment landscape in hematological and solid tumor cancers. Improvements in constructs of CAR-T have improved specificity in targeting malignant cells. Multiple clinical trials have demonstrated the efficacy of CAR-T and other cellular treatments. In spite of advances in cellular therapies, hurdles in managing toxicities and lingering resistance remain. This review aims to summarize current innovations in adoptive cellular therapies and introduces future paths of discovery that will enhance these therapies in the era of precision oncology.Peihua LuHolly A. HillLucy J. NavsariaMichael L. WangElsevierarticleChimeric antigen receptorAdoptive cell therapyB cell malignanciesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the National Cancer Center, Vol 1, Iss 3, Pp 88-96 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chimeric antigen receptor Adoptive cell therapy B cell malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Chimeric antigen receptor Adoptive cell therapy B cell malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Peihua Lu Holly A. Hill Lucy J. Navsaria Michael L. Wang CAR-T and other adoptive cell therapies for B cell malignancies
description	B cell malignancies pose challenges due to therapeutic resistance and repeated relapse. Advances in adoptive cellular therapies including chimeric antigen receptor (CAR)-T cells have the potential to transform the treatment landscape in hematological and solid tumor cancers. Improvements in constructs of CAR-T have improved specificity in targeting malignant cells. Multiple clinical trials have demonstrated the efficacy of CAR-T and other cellular treatments. In spite of advances in cellular therapies, hurdles in managing toxicities and lingering resistance remain. This review aims to summarize current innovations in adoptive cellular therapies and introduces future paths of discovery that will enhance these therapies in the era of precision oncology.
format	article
author	Peihua Lu Holly A. Hill Lucy J. Navsaria Michael L. Wang
author_facet	Peihua Lu Holly A. Hill Lucy J. Navsaria Michael L. Wang
author_sort	Peihua Lu
title	CAR-T and other adoptive cell therapies for B cell malignancies
title_short	CAR-T and other adoptive cell therapies for B cell malignancies
title_full	CAR-T and other adoptive cell therapies for B cell malignancies
title_fullStr	CAR-T and other adoptive cell therapies for B cell malignancies
title_full_unstemmed	CAR-T and other adoptive cell therapies for B cell malignancies
title_sort	car-t and other adoptive cell therapies for b cell malignancies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/13baf7e057a4433f9f07fc68916d37eb
work_keys_str_mv	AT peihualu cartandotheradoptivecelltherapiesforbcellmalignancies AT hollyahill cartandotheradoptivecelltherapiesforbcellmalignancies AT lucyjnavsaria cartandotheradoptivecelltherapiesforbcellmalignancies AT michaellwang cartandotheradoptivecelltherapiesforbcellmalignancies
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CAR-T and other adoptive cell therapies for B cell malignancies

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