Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache

The precise mechanisms that lead to medication-overuse headaches (MOH), which can occur with both over-the-counter and prescription pain-relief medicines, are still uncertain. In this study, authors show that the abnormal activation of dural nociceptor Nav1.9 channels by Nitric Oxide is responsible...

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Autores principales:	Caroline Bonnet, Jizhe Hao, Nancy Osorio, Anne Donnet, Virginie Penalba, Jérôme Ruel, Patrick Delmas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13bb724449b94f508ae02468f5087389
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spelling	oai:doaj.org-article:13bb724449b94f508ae02468f50873892021-12-02T17:31:22ZMaladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache10.1038/s41467-019-12197-32041-1723https://doaj.org/article/13bb724449b94f508ae02468f50873892019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12197-3https://doaj.org/toc/2041-1723The precise mechanisms that lead to medication-overuse headaches (MOH), which can occur with both over-the-counter and prescription pain-relief medicines, are still uncertain. In this study, authors show that the abnormal activation of dural nociceptor Nav1.9 channels by Nitric Oxide is responsible for triptan-induced MOH, causing hyperexcitability of dural nociceptors and headache.Caroline BonnetJizhe HaoNancy OsorioAnne DonnetVirginie PenalbaJérôme RuelPatrick DelmasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline Bonnet Jizhe Hao Nancy Osorio Anne Donnet Virginie Penalba Jérôme Ruel Patrick Delmas Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
description	The precise mechanisms that lead to medication-overuse headaches (MOH), which can occur with both over-the-counter and prescription pain-relief medicines, are still uncertain. In this study, authors show that the abnormal activation of dural nociceptor Nav1.9 channels by Nitric Oxide is responsible for triptan-induced MOH, causing hyperexcitability of dural nociceptors and headache.
format	article
author	Caroline Bonnet Jizhe Hao Nancy Osorio Anne Donnet Virginie Penalba Jérôme Ruel Patrick Delmas
author_facet	Caroline Bonnet Jizhe Hao Nancy Osorio Anne Donnet Virginie Penalba Jérôme Ruel Patrick Delmas
author_sort	Caroline Bonnet
title	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
title_short	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
title_full	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
title_fullStr	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
title_full_unstemmed	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
title_sort	maladaptive activation of nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/13bb724449b94f508ae02468f5087389
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Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache

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