Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache

The precise mechanisms that lead to medication-overuse headaches (MOH), which can occur with both over-the-counter and prescription pain-relief medicines, are still uncertain. In this study, authors show that the abnormal activation of dural nociceptor Nav1.9 channels by Nitric Oxide is responsible...

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Autores principales: Caroline Bonnet, Jizhe Hao, Nancy Osorio, Anne Donnet, Virginie Penalba, Jérôme Ruel, Patrick Delmas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/13bb724449b94f508ae02468f5087389
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