STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.

Intestinal stem cells play a pivotal role in the epithelial tissue renewal, homeostasis and cancer development. The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their adaptive changes upon intestinal lesions or d...

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Autores principales:	Zhengyuan Wang, Paul Matsudaira, Zhiyuan Gong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13bc3ff4486c4a9aaee1fda7fa2da4b0
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spelling	oai:doaj.org-article:13bc3ff4486c4a9aaee1fda7fa2da4b02021-11-18T07:36:41ZSTORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.1932-620310.1371/journal.pone.0014063https://doaj.org/article/13bc3ff4486c4a9aaee1fda7fa2da4b02010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21124758/?tool=EBIhttps://doaj.org/toc/1932-6203Intestinal stem cells play a pivotal role in the epithelial tissue renewal, homeostasis and cancer development. The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their adaptive changes upon intestinal lesions or during development of cancer. Here a two-dimensional model, named STORM, has been developed to address this issue. By optimizing epithelium renewal dynamics, the model examines the epithelial stem cell number by taking experimental input information regarding epithelium proliferation and differentiation. As the results suggest, there are 2.0-4.1 epithelial stem cells on each pocket section of zebrafish intestine, 2.0-4.1 stem cells on each crypt section of murine small intestine and 1.8-3.5 stem cells on each crypt section of human duodenum. The model is able to provide quick results for stem cell number and its adaptive changes, which is not easy to measure through experiments. Its general applicability to different species makes it a valuable tool for analysis of intestinal stem cells under various pathological conditions.Zhengyuan WangPaul MatsudairaZhiyuan GongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e14063 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhengyuan Wang Paul Matsudaira Zhiyuan Gong STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
description	Intestinal stem cells play a pivotal role in the epithelial tissue renewal, homeostasis and cancer development. The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their adaptive changes upon intestinal lesions or during development of cancer. Here a two-dimensional model, named STORM, has been developed to address this issue. By optimizing epithelium renewal dynamics, the model examines the epithelial stem cell number by taking experimental input information regarding epithelium proliferation and differentiation. As the results suggest, there are 2.0-4.1 epithelial stem cells on each pocket section of zebrafish intestine, 2.0-4.1 stem cells on each crypt section of murine small intestine and 1.8-3.5 stem cells on each crypt section of human duodenum. The model is able to provide quick results for stem cell number and its adaptive changes, which is not easy to measure through experiments. Its general applicability to different species makes it a valuable tool for analysis of intestinal stem cells under various pathological conditions.
format	article
author	Zhengyuan Wang Paul Matsudaira Zhiyuan Gong
author_facet	Zhengyuan Wang Paul Matsudaira Zhiyuan Gong
author_sort	Zhengyuan Wang
title	STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
title_short	STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
title_full	STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
title_fullStr	STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
title_full_unstemmed	STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
title_sort	storm: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/13bc3ff4486c4a9aaee1fda7fa2da4b0
work_keys_str_mv	AT zhengyuanwang stormageneralmodeltodeterminethenumberandadaptivechangesofepithelialstemcellsinteleostmurineandhumanintestinaltracts AT paulmatsudaira stormageneralmodeltodeterminethenumberandadaptivechangesofepithelialstemcellsinteleostmurineandhumanintestinaltracts AT zhiyuangong stormageneralmodeltodeterminethenumberandadaptivechangesofepithelialstemcellsinteleostmurineandhumanintestinaltracts
_version_	1718423143910998016

STORM: a general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts.

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