mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

mTOR regulates cell growth via a protein complex including mTORC1 and mTORC2, but their role in skin morphogenesis is unclear. Here, the authors delete mTORC1 and mTORC2 from the epidermis and see epidermal deficiencies but both mTORCs play distinct roles in skin morphogenesis.

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Autores principales:	Xiaolei Ding, Wilhelm Bloch, Sandra Iden, Markus A. Rüegg, Michael N. Hall, Maria Leptin, Linda Partridge, Sabine A. Eming
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13c10d0d38324a9ba4a52ca390cb9bc2
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spelling	oai:doaj.org-article:13c10d0d38324a9ba4a52ca390cb9bc22021-12-02T15:35:41ZmTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation10.1038/ncomms132262041-1723https://doaj.org/article/13c10d0d38324a9ba4a52ca390cb9bc22016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13226https://doaj.org/toc/2041-1723mTOR regulates cell growth via a protein complex including mTORC1 and mTORC2, but their role in skin morphogenesis is unclear. Here, the authors delete mTORC1 and mTORC2 from the epidermis and see epidermal deficiencies but both mTORCs play distinct roles in skin morphogenesis.Xiaolei DingWilhelm BlochSandra IdenMarkus A. RüeggMichael N. HallMaria LeptinLinda PartridgeSabine A. EmingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaolei Ding Wilhelm Bloch Sandra Iden Markus A. Rüegg Michael N. Hall Maria Leptin Linda Partridge Sabine A. Eming mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
description	mTOR regulates cell growth via a protein complex including mTORC1 and mTORC2, but their role in skin morphogenesis is unclear. Here, the authors delete mTORC1 and mTORC2 from the epidermis and see epidermal deficiencies but both mTORCs play distinct roles in skin morphogenesis.
format	article
author	Xiaolei Ding Wilhelm Bloch Sandra Iden Markus A. Rüegg Michael N. Hall Maria Leptin Linda Partridge Sabine A. Eming
author_facet	Xiaolei Ding Wilhelm Bloch Sandra Iden Markus A. Rüegg Michael N. Hall Maria Leptin Linda Partridge Sabine A. Eming
author_sort	Xiaolei Ding
title	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
title_short	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
title_full	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
title_fullStr	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
title_full_unstemmed	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
title_sort	mtorc1 and mtorc2 regulate skin morphogenesis and epidermal barrier formation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/13c10d0d38324a9ba4a52ca390cb9bc2
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mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

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