Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

Abstract Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB s...

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Autores principales:	Maria Rossing, Christina Bligaard Pedersen, Tove Tvedskov, Ilse Vejborg, Maj-Lis Talman, Lars Rønn Olsen, Niels Kroman, Finn Cilius Nielsen, Maj-Britt Jensen, Bent Ejlertsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13c2c9c1e720439e810b95af12a02f1c
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spelling	oai:doaj.org-article:13c2c9c1e720439e810b95af12a02f1c2021-12-02T13:57:58ZClinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status10.1038/s41598-021-81538-42045-2322https://doaj.org/article/13c2c9c1e720439e810b95af12a02f1c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81538-4https://doaj.org/toc/2045-2322Abstract Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a breast cancer > 10 mm underwent primary surgical procedure including SLNB and tumor specimens were assigned with a transcriptomics-based molecular subtype. 1020 patients had a negative sentinel node (SN) and 536 a positive. A significant association between tumor size and SN status (p < 0.0001) was found across all samples, but no association between size and SN status (p = 0.14) was found for BasL tumors. A BasL subtype was a predictor of an SN-negative status (p = 0.001, OR 0.58, 95% CI 0.38;0.90) and among the BasL, postmenopausal status was a predictor for SN-negative status (p = 0.01). Overall survival was significantly lower (p = 0.02) in patients with BasL tumors and a positive SN. Interestingly, we identified a significant correlation between hormone receptor activity and SN status within the BasL subtype. Taken together, molecular subtypes and hormone receptor activity of breast cancers add predictive value for SLNB status.Maria RossingChristina Bligaard PedersenTove TvedskovIlse VejborgMaj-Lis TalmanLars Rønn OlsenNiels KromanFinn Cilius NielsenMaj-Britt JensenBent EjlertsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Rossing Christina Bligaard Pedersen Tove Tvedskov Ilse Vejborg Maj-Lis Talman Lars Rønn Olsen Niels Kroman Finn Cilius Nielsen Maj-Britt Jensen Bent Ejlertsen Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
description	Abstract Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a breast cancer > 10 mm underwent primary surgical procedure including SLNB and tumor specimens were assigned with a transcriptomics-based molecular subtype. 1020 patients had a negative sentinel node (SN) and 536 a positive. A significant association between tumor size and SN status (p < 0.0001) was found across all samples, but no association between size and SN status (p = 0.14) was found for BasL tumors. A BasL subtype was a predictor of an SN-negative status (p = 0.001, OR 0.58, 95% CI 0.38;0.90) and among the BasL, postmenopausal status was a predictor for SN-negative status (p = 0.01). Overall survival was significantly lower (p = 0.02) in patients with BasL tumors and a positive SN. Interestingly, we identified a significant correlation between hormone receptor activity and SN status within the BasL subtype. Taken together, molecular subtypes and hormone receptor activity of breast cancers add predictive value for SLNB status.
format	article
author	Maria Rossing Christina Bligaard Pedersen Tove Tvedskov Ilse Vejborg Maj-Lis Talman Lars Rønn Olsen Niels Kroman Finn Cilius Nielsen Maj-Britt Jensen Bent Ejlertsen
author_facet	Maria Rossing Christina Bligaard Pedersen Tove Tvedskov Ilse Vejborg Maj-Lis Talman Lars Rønn Olsen Niels Kroman Finn Cilius Nielsen Maj-Britt Jensen Bent Ejlertsen
author_sort	Maria Rossing
title	Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
title_short	Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
title_full	Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
title_fullStr	Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
title_full_unstemmed	Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
title_sort	clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13c2c9c1e720439e810b95af12a02f1c
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Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

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