Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review

Abstract Background Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous liter...

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Autores principales:	Bin Zhang, Miao Bai, Runfa Tian, Shuyu Hao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Myxofibrosarcoma Head and neck Planned surgery Gross total resection Bin Zhang and Miao Bai are co-first authors Surgery RD1-811 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/13c3742fb3d44017a54c42f0dd3cd3bd
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spelling	oai:doaj.org-article:13c3742fb3d44017a54c42f0dd3cd3bd2021-11-28T12:22:29ZIdiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review10.1186/s41016-021-00267-92057-4967https://doaj.org/article/13c3742fb3d44017a54c42f0dd3cd3bd2021-11-01T00:00:00Zhttps://doi.org/10.1186/s41016-021-00267-9https://doaj.org/toc/2057-4967Abstract Background Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous literature, the clinical features, essentials of diagnosis, and treatment modalities of MFS in the head and neck were reviewed to better understand this rare entity. Case presentation We reported a case of RIMFS under the left occipital scalp in a 20-year-old girl with a history of medulloblastoma surgery and radiotherapy in 2006. A total tumor resection was performed with preservation of the overlying scalp the underlying bone, and no adjuvant therapy was administered after the first operation. The postoperative pathological diagnosis was high-grade MFS. The tumor relapsed 6 months later, and then, a planned extensive resection with negative surgical margins was carried out, followed by radiotherapy. No relapse occurred in a 12-month postoperative follow-up. Conclusions Planned gross total resection (GTR) with negative margins is the reasonable choice and footstone of other treatments for MFS. Ill-defined infiltrated borders and the complicated structures make it a great trouble to achieve total resection of MFS in the head and neck, so adjuvant radiotherapy and chemotherapy seem more necessary for these lesions.Bin ZhangMiao BaiRunfa TianShuyu HaoBMCarticleMyxofibrosarcomaHead and neckPlanned surgeryGross total resectionBin Zhang and Miao Bai are co-first authorsSurgeryRD1-811Neurology. Diseases of the nervous systemRC346-429ENChinese Neurosurgical Journal, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Myxofibrosarcoma Head and neck Planned surgery Gross total resection Bin Zhang and Miao Bai are co-first authors Surgery RD1-811 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Myxofibrosarcoma Head and neck Planned surgery Gross total resection Bin Zhang and Miao Bai are co-first authors Surgery RD1-811 Neurology. Diseases of the nervous system RC346-429 Bin Zhang Miao Bai Runfa Tian Shuyu Hao Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
description	Abstract Background Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous literature, the clinical features, essentials of diagnosis, and treatment modalities of MFS in the head and neck were reviewed to better understand this rare entity. Case presentation We reported a case of RIMFS under the left occipital scalp in a 20-year-old girl with a history of medulloblastoma surgery and radiotherapy in 2006. A total tumor resection was performed with preservation of the overlying scalp the underlying bone, and no adjuvant therapy was administered after the first operation. The postoperative pathological diagnosis was high-grade MFS. The tumor relapsed 6 months later, and then, a planned extensive resection with negative surgical margins was carried out, followed by radiotherapy. No relapse occurred in a 12-month postoperative follow-up. Conclusions Planned gross total resection (GTR) with negative margins is the reasonable choice and footstone of other treatments for MFS. Ill-defined infiltrated borders and the complicated structures make it a great trouble to achieve total resection of MFS in the head and neck, so adjuvant radiotherapy and chemotherapy seem more necessary for these lesions.
format	article
author	Bin Zhang Miao Bai Runfa Tian Shuyu Hao
author_facet	Bin Zhang Miao Bai Runfa Tian Shuyu Hao
author_sort	Bin Zhang
title	Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
title_short	Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
title_full	Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
title_fullStr	Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
title_full_unstemmed	Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
title_sort	idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/13c3742fb3d44017a54c42f0dd3cd3bd
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Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review

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