N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular c...

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Autores principales:	Yanying Wang, Jing Wang, Xiaoyu Li, Xushen Xiong, Jianyi Wang, Ziheng Zhou, Xiaoxiao Zhu, Yang Gu, Dan Dominissini, Lei He, Yong Tian, Chengqi Yi, Zusen Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13c5a25590da4573bc3cc56bbda89738
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spelling	oai:doaj.org-article:13c5a25590da4573bc3cc56bbda897382021-11-08T11:12:51ZN 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism10.1038/s41467-021-26718-62041-1723https://doaj.org/article/13c5a25590da4573bc3cc56bbda897382021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26718-6https://doaj.org/toc/2041-1723Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma.Yanying WangJing WangXiaoyu LiXushen XiongJianyi WangZiheng ZhouXiaoxiao ZhuYang GuDan DominissiniLei HeYong TianChengqi YiZusen FanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanying Wang Jing Wang Xiaoyu Li Xushen Xiong Jianyi Wang Ziheng Zhou Xiaoxiao Zhu Yang Gu Dan Dominissini Lei He Yong Tian Chengqi Yi Zusen Fan N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
description	Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma.
format	article
author	Yanying Wang Jing Wang Xiaoyu Li Xushen Xiong Jianyi Wang Ziheng Zhou Xiaoxiao Zhu Yang Gu Dan Dominissini Lei He Yong Tian Chengqi Yi Zusen Fan
author_facet	Yanying Wang Jing Wang Xiaoyu Li Xushen Xiong Jianyi Wang Ziheng Zhou Xiaoxiao Zhu Yang Gu Dan Dominissini Lei He Yong Tian Chengqi Yi Zusen Fan
author_sort	Yanying Wang
title	N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
title_short	N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
title_full	N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
title_fullStr	N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
title_full_unstemmed	N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
title_sort	n 1-methyladenosine methylation in trna drives liver tumourigenesis by regulating cholesterol metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13c5a25590da4573bc3cc56bbda89738
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N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

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