Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice

Abstract Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related be...

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Autores principales:	Carlos Dombret, Lydie Naulé, Anne-Charlotte Trouillet, Caroline Parmentier, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13c62b1ac1494c4b928cf5b5ac50dba2
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spelling	oai:doaj.org-article:13c62b1ac1494c4b928cf5b5ac50dba22021-12-02T18:15:09ZEffects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice10.1038/s41598-020-63427-42045-2322https://doaj.org/article/13c62b1ac1494c4b928cf5b5ac50dba22020-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-63427-4https://doaj.org/toc/2045-2322Abstract Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lacking the ERβ gene in the nervous system. Mutant males exhibited reduced social interaction with same-sex congeners and impaired aggressive behavior. They also displayed increased locomotor activity, and reduced or unaffected anxiety-state level in three paradigms. However, when mice were exposed to unescapable stress in the forced swim and tail suspension tests, they spent more time immobile and a reduced time in swimming and climbing. These behavioral alterations were associated with unaffected circadian and restraint stress-induced corticosterone levels, and unchanged number of tryptophan hydroxylase 2-immunoreactive neurons in the dorsal raphe. By contrast, reduced mRNA levels of oxytocin and arginine-vasopressin were observed in the bed nucleus of stria terminalis, whereas no changes were detected in the hypothalamic paraventricular nucleus. The neural ERβ is thus involved to different extent levels in social and mood-related behaviors, with a particular action on oxytocin and arginine-vasopressin signaling pathways of the bed nucleus of stria terminalis, yet the involvement of other brain areas cannot be excluded.Carlos DombretLydie NauléAnne-Charlotte TrouilletCaroline ParmentierHélène Hardin-PouzetSakina Mhaouty-KodjaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos Dombret Lydie Naulé Anne-Charlotte Trouillet Caroline Parmentier Hélène Hardin-Pouzet Sakina Mhaouty-Kodja Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
description	Abstract Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lacking the ERβ gene in the nervous system. Mutant males exhibited reduced social interaction with same-sex congeners and impaired aggressive behavior. They also displayed increased locomotor activity, and reduced or unaffected anxiety-state level in three paradigms. However, when mice were exposed to unescapable stress in the forced swim and tail suspension tests, they spent more time immobile and a reduced time in swimming and climbing. These behavioral alterations were associated with unaffected circadian and restraint stress-induced corticosterone levels, and unchanged number of tryptophan hydroxylase 2-immunoreactive neurons in the dorsal raphe. By contrast, reduced mRNA levels of oxytocin and arginine-vasopressin were observed in the bed nucleus of stria terminalis, whereas no changes were detected in the hypothalamic paraventricular nucleus. The neural ERβ is thus involved to different extent levels in social and mood-related behaviors, with a particular action on oxytocin and arginine-vasopressin signaling pathways of the bed nucleus of stria terminalis, yet the involvement of other brain areas cannot be excluded.
format	article
author	Carlos Dombret Lydie Naulé Anne-Charlotte Trouillet Caroline Parmentier Hélène Hardin-Pouzet Sakina Mhaouty-Kodja
author_facet	Carlos Dombret Lydie Naulé Anne-Charlotte Trouillet Caroline Parmentier Hélène Hardin-Pouzet Sakina Mhaouty-Kodja
author_sort	Carlos Dombret
title	Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_short	Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_full	Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_fullStr	Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_full_unstemmed	Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_sort	effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/13c62b1ac1494c4b928cf5b5ac50dba2
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Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice

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