Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets

Comparing and contrasting structural ensembles of different protein variants helps connect specific structural features to a protein’s biochemical properties. Here, the authors propose DiffNets, a self-supervised, deep learning method that streamlines this process.

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Detalles Bibliográficos
Autores principales: Michael D. Ward, Maxwell I. Zimmerman, Artur Meller, Moses Chung, S. J. Swamidass, Gregory R. Bowman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/13c6be6650f24dc28b6a7660d1256cac
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Sumario:Comparing and contrasting structural ensembles of different protein variants helps connect specific structural features to a protein’s biochemical properties. Here, the authors propose DiffNets, a self-supervised, deep learning method that streamlines this process.