A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes

Berberine ursodeoxycholate has been studied for its serum lipid and lipoprotein lowering effects. Here the authors report an 18-week phase 2, randomised, double-blind, placebo-controlled clinical trial that tested the effect of berberine ursodeoxycholate in patients with fatty liver disease and diab...

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Autores principales:	Stephen A. Harrison, Nadege Gunn, Guy W. Neff, Anita Kohli, Liping Liu, Abbey Flyer, Lawrence Goldkind, Adrian M. Di Bisceglie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13c7aeb937eb489ca602dac9be76c850
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spelling	oai:doaj.org-article:13c7aeb937eb489ca602dac9be76c8502021-12-02T17:23:48ZA phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes10.1038/s41467-021-25701-52041-1723https://doaj.org/article/13c7aeb937eb489ca602dac9be76c8502021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25701-5https://doaj.org/toc/2041-1723Berberine ursodeoxycholate has been studied for its serum lipid and lipoprotein lowering effects. Here the authors report an 18-week phase 2, randomised, double-blind, placebo-controlled clinical trial that tested the effect of berberine ursodeoxycholate in patients with fatty liver disease and diabetes, and showed that the group taking the higher dose of the drug had reduced liver fat content.Stephen A. HarrisonNadege GunnGuy W. NeffAnita KohliLiping LiuAbbey FlyerLawrence GoldkindAdrian M. Di BisceglieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen A. Harrison Nadege Gunn Guy W. Neff Anita Kohli Liping Liu Abbey Flyer Lawrence Goldkind Adrian M. Di Bisceglie A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
description	Berberine ursodeoxycholate has been studied for its serum lipid and lipoprotein lowering effects. Here the authors report an 18-week phase 2, randomised, double-blind, placebo-controlled clinical trial that tested the effect of berberine ursodeoxycholate in patients with fatty liver disease and diabetes, and showed that the group taking the higher dose of the drug had reduced liver fat content.
format	article
author	Stephen A. Harrison Nadege Gunn Guy W. Neff Anita Kohli Liping Liu Abbey Flyer Lawrence Goldkind Adrian M. Di Bisceglie
author_facet	Stephen A. Harrison Nadege Gunn Guy W. Neff Anita Kohli Liping Liu Abbey Flyer Lawrence Goldkind Adrian M. Di Bisceglie
author_sort	Stephen A. Harrison
title	A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
title_short	A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
title_full	A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
title_fullStr	A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
title_full_unstemmed	A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
title_sort	phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13c7aeb937eb489ca602dac9be76c850
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A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes

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