Modulation of Cellular NAD<sup>+</sup> Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps

Modulation of Cellular NAD<sup>+</sup> Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps

Cancer-associated thrombosis is the second-leading cause of mortality in patients with cancer and presents a poor prognosis, with a lack of effective treatment strategies. NAD(P)H quinone oxidoreductase 1 (NQO1) increases the cellular nicotinamide adenine dinucleotide (NAD<sup>+</sup>) l...

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Main Authors: Wa Cao, Meng-Yu Zhu, Seung-Hoon Lee, Su-Bin Lee, Hyung-Jin Kim, Byung-Ouk Park, Cheol-Hwan Yoon, Dipendra Khadka, Gi-Su Oh, Hyeok Shim, Tae-Hwan Kwak, Hong-Seob So
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
cancer-associated thrombosis
NAD<sup>+</sup>
dunnione
tissue factor
NETs
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/13c7afa97e9841b28f1e57e3c3b7e482
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https://doaj.org/article/13c7afa97e9841b28f1e57e3c3b7e482

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