Study of mouse behavior in different gravity environments

Abstract Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study, we developed a simple Active Inactiv...

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Autores principales:	Michihiko Shimomura, Akane Yumoto, Naoko Ota-Murakami, Takashi Kudo, Masaki Shirakawa, Satoru Takahashi, Hironobu Morita, Dai Shiba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13c7ded9121a4732bb735721e51abf09
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spelling	oai:doaj.org-article:13c7ded9121a4732bb735721e51abf092021-12-02T14:16:57ZStudy of mouse behavior in different gravity environments10.1038/s41598-021-82013-w2045-2322https://doaj.org/article/13c7ded9121a4732bb735721e51abf092021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82013-whttps://doaj.org/toc/2045-2322Abstract Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study, we developed a simple Active Inactive Separation (AIS) method to extract activity and inactivity in videos obtained from the habitat cage unit of a space experiment. This method yields an activity ratio as a ratio of ‘activity’ within the whole. Adaptation to different gravitational conditions from 1g to hypergravity (HG) and from microgravity (MG) to artificial 1g (AG) was analyzed based on the amount of activity to calculate the activity ratio and the active interval. The result for the activity ratios for the ground control experiment using AIS were close to previous studies, so the effectiveness of this method was indicated. In the case of changes in gravity from 1g to HG, the ratio was low at the start of centrifugation, recovered sharply in the first week, and entered a stable period in another week. The trend in the AG and HG was the same; adapting to different gravity environments takes time.Michihiko ShimomuraAkane YumotoNaoko Ota-MurakamiTakashi KudoMasaki ShirakawaSatoru TakahashiHironobu MoritaDai ShibaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michihiko Shimomura Akane Yumoto Naoko Ota-Murakami Takashi Kudo Masaki Shirakawa Satoru Takahashi Hironobu Morita Dai Shiba Study of mouse behavior in different gravity environments
description	Abstract Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study, we developed a simple Active Inactive Separation (AIS) method to extract activity and inactivity in videos obtained from the habitat cage unit of a space experiment. This method yields an activity ratio as a ratio of ‘activity’ within the whole. Adaptation to different gravitational conditions from 1g to hypergravity (HG) and from microgravity (MG) to artificial 1g (AG) was analyzed based on the amount of activity to calculate the activity ratio and the active interval. The result for the activity ratios for the ground control experiment using AIS were close to previous studies, so the effectiveness of this method was indicated. In the case of changes in gravity from 1g to HG, the ratio was low at the start of centrifugation, recovered sharply in the first week, and entered a stable period in another week. The trend in the AG and HG was the same; adapting to different gravity environments takes time.
format	article
author	Michihiko Shimomura Akane Yumoto Naoko Ota-Murakami Takashi Kudo Masaki Shirakawa Satoru Takahashi Hironobu Morita Dai Shiba
author_facet	Michihiko Shimomura Akane Yumoto Naoko Ota-Murakami Takashi Kudo Masaki Shirakawa Satoru Takahashi Hironobu Morita Dai Shiba
author_sort	Michihiko Shimomura
title	Study of mouse behavior in different gravity environments
title_short	Study of mouse behavior in different gravity environments
title_full	Study of mouse behavior in different gravity environments
title_fullStr	Study of mouse behavior in different gravity environments
title_full_unstemmed	Study of mouse behavior in different gravity environments
title_sort	study of mouse behavior in different gravity environments
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13c7ded9121a4732bb735721e51abf09
work_keys_str_mv	AT michihikoshimomura studyofmousebehaviorindifferentgravityenvironments AT akaneyumoto studyofmousebehaviorindifferentgravityenvironments AT naokootamurakami studyofmousebehaviorindifferentgravityenvironments AT takashikudo studyofmousebehaviorindifferentgravityenvironments AT masakishirakawa studyofmousebehaviorindifferentgravityenvironments AT satorutakahashi studyofmousebehaviorindifferentgravityenvironments AT hironobumorita studyofmousebehaviorindifferentgravityenvironments AT daishiba studyofmousebehaviorindifferentgravityenvironments
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Study of mouse behavior in different gravity environments

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