Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China

In order to estimate the associations of different adiposity indicators and long-term adiposity changes with risk of incident type 2 diabetes (T2DM), we conducted a 10-year prospective cohort study of 7441 adults in Guizhou, China, from 2010 to 2020. Adiposity was measured at baseline and follow-up....

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Autores principales:	Yun Chen, Yiying Wang, Kelin Xu, Jie Zhou, Lisha Yu, Na Wang, Tao Liu, Chaowei Fu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	general obesity abdominal obesity long-term adiposity change type 2 diabetes cohort study Medicine R
Acceso en línea:	https://doaj.org/article/13cb355152244a5da5137e72c5676eff
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spelling	oai:doaj.org-article:13cb355152244a5da5137e72c5676eff2021-11-11T16:36:26ZAdiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China10.3390/ijerph1821114811660-46011661-7827https://doaj.org/article/13cb355152244a5da5137e72c5676eff2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11481https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601In order to estimate the associations of different adiposity indicators and long-term adiposity changes with risk of incident type 2 diabetes (T2DM), we conducted a 10-year prospective cohort study of 7441 adults in Guizhou, China, from 2010 to 2020. Adiposity was measured at baseline and follow-up. Cox proportional hazard models were used to estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs). A total of 764 new diabetes cases were identified over an average follow-up of 7.06 years. Adiposity indicators, body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), and long-term adiposity changes (both weight change and WC change) were significantly associated with an increased risk of T2DM (adjusted HRs: 1.16–1.48). Significant non-linear relationships were found between weight/WC change and incident T2DM. Compared with subjects with stable WC from baseline to follow-up visit, the subjects with WC gain ≥9 cm had a 1.61-fold greater risk of T2DM; those with WC loss had a 30% lower risk. Furthermore, the associations were stronger among participants aged 40 years or older, women, and Han Chinese. Preventing weight or WC gain and promoting maintenance of normal body weight or WC are important approaches for diabetes prevention, especially for the elderly, women, and Han Chinese.Yun ChenYiying WangKelin XuJie ZhouLisha YuNa WangTao LiuChaowei FuMDPI AGarticlegeneral obesityabdominal obesitylong-term adiposity changetype 2 diabetescohort studyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11481, p 11481 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	general obesity abdominal obesity long-term adiposity change type 2 diabetes cohort study Medicine R
spellingShingle	general obesity abdominal obesity long-term adiposity change type 2 diabetes cohort study Medicine R Yun Chen Yiying Wang Kelin Xu Jie Zhou Lisha Yu Na Wang Tao Liu Chaowei Fu Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China
description	In order to estimate the associations of different adiposity indicators and long-term adiposity changes with risk of incident type 2 diabetes (T2DM), we conducted a 10-year prospective cohort study of 7441 adults in Guizhou, China, from 2010 to 2020. Adiposity was measured at baseline and follow-up. Cox proportional hazard models were used to estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs). A total of 764 new diabetes cases were identified over an average follow-up of 7.06 years. Adiposity indicators, body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), and long-term adiposity changes (both weight change and WC change) were significantly associated with an increased risk of T2DM (adjusted HRs: 1.16–1.48). Significant non-linear relationships were found between weight/WC change and incident T2DM. Compared with subjects with stable WC from baseline to follow-up visit, the subjects with WC gain ≥9 cm had a 1.61-fold greater risk of T2DM; those with WC loss had a 30% lower risk. Furthermore, the associations were stronger among participants aged 40 years or older, women, and Han Chinese. Preventing weight or WC gain and promoting maintenance of normal body weight or WC are important approaches for diabetes prevention, especially for the elderly, women, and Han Chinese.
format	article
author	Yun Chen Yiying Wang Kelin Xu Jie Zhou Lisha Yu Na Wang Tao Liu Chaowei Fu
author_facet	Yun Chen Yiying Wang Kelin Xu Jie Zhou Lisha Yu Na Wang Tao Liu Chaowei Fu
author_sort	Yun Chen
title	Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China
title_short	Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China
title_full	Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China
title_fullStr	Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China
title_full_unstemmed	Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China
title_sort	adiposity and long-term adiposity change are associated with incident diabetes: a prospective cohort study in southwest china
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/13cb355152244a5da5137e72c5676eff
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Adiposity and Long-Term Adiposity Change Are Associated with Incident Diabetes: A Prospective Cohort Study in Southwest China

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