Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket

In some countries, leaves of the shrub Mallotus oppositifolius have been used to treat epilepsy. Here, authors look at the structural and molecular basis for how chemical components of M. oppositifolius have their anticonvulsant effects, via modulation of potassium channel activity.

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Detalles Bibliográficos
Autores principales:	Rían W. Manville, Geoffrey W. Abbott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13ce9be6f195458894bf04afebd01570
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spelling	oai:doaj.org-article:13ce9be6f195458894bf04afebd015702021-12-02T17:32:44ZAncient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket10.1038/s41467-018-06339-22041-1723https://doaj.org/article/13ce9be6f195458894bf04afebd015702018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06339-2https://doaj.org/toc/2041-1723In some countries, leaves of the shrub Mallotus oppositifolius have been used to treat epilepsy. Here, authors look at the structural and molecular basis for how chemical components of M. oppositifolius have their anticonvulsant effects, via modulation of potassium channel activity.Rían W. ManvilleGeoffrey W. AbbottNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rían W. Manville Geoffrey W. Abbott Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
description	In some countries, leaves of the shrub Mallotus oppositifolius have been used to treat epilepsy. Here, authors look at the structural and molecular basis for how chemical components of M. oppositifolius have their anticonvulsant effects, via modulation of potassium channel activity.
format	article
author	Rían W. Manville Geoffrey W. Abbott
author_facet	Rían W. Manville Geoffrey W. Abbott
author_sort	Rían W. Manville
title	Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
title_short	Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
title_full	Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
title_fullStr	Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
title_full_unstemmed	Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
title_sort	ancient and modern anticonvulsants act synergistically in a kcnq potassium channel binding pocket
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/13ce9be6f195458894bf04afebd01570
work_keys_str_mv	AT rianwmanville ancientandmodernanticonvulsantsactsynergisticallyinakcnqpotassiumchannelbindingpocket AT geoffreywabbott ancientandmodernanticonvulsantsactsynergisticallyinakcnqpotassiumchannelbindingpocket
_version_	1718380170105061376

Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket

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