Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the transcription of a subset of TGF-beta genes.

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Autores principales:	Virginia Murillo-Garzón, Irantzu Gorroño-Etxebarria, Malin Åkerfelt, Mikael Christer Puustinen, Lea Sistonen, Matthias Nees, James Carton, Jonathan Waxman, Robert M. Kypta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13cee405e09b4dc9b930c14c87af3723
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spelling	oai:doaj.org-article:13cee405e09b4dc9b930c14c87af37232021-12-02T15:34:02ZFrizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer10.1038/s41467-018-04042-w2041-1723https://doaj.org/article/13cee405e09b4dc9b930c14c87af37232018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04042-whttps://doaj.org/toc/2041-1723Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the transcription of a subset of TGF-beta genes.Virginia Murillo-GarzónIrantzu Gorroño-EtxebarriaMalin ÅkerfeltMikael Christer PuustinenLea SistonenMatthias NeesJames CartonJonathan WaxmanRobert M. KyptaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Virginia Murillo-Garzón Irantzu Gorroño-Etxebarria Malin Åkerfelt Mikael Christer Puustinen Lea Sistonen Matthias Nees James Carton Jonathan Waxman Robert M. Kypta Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
description	Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the transcription of a subset of TGF-beta genes.
format	article
author	Virginia Murillo-Garzón Irantzu Gorroño-Etxebarria Malin Åkerfelt Mikael Christer Puustinen Lea Sistonen Matthias Nees James Carton Jonathan Waxman Robert M. Kypta
author_facet	Virginia Murillo-Garzón Irantzu Gorroño-Etxebarria Malin Åkerfelt Mikael Christer Puustinen Lea Sistonen Matthias Nees James Carton Jonathan Waxman Robert M. Kypta
author_sort	Virginia Murillo-Garzón
title	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
title_short	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
title_full	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
title_fullStr	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
title_full_unstemmed	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
title_sort	frizzled-8 integrates wnt-11 and transforming growth factor-β signaling in prostate cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/13cee405e09b4dc9b930c14c87af3723
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Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

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