Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo

Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah Al-Mohy, Mohammed Suliman Al-Ayed Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and in...

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Autores principales:	Abdelhalim MAK, Qaid HAY, Al-Mohy Y, Al-Ayed MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gold nanoparticles nephrotoxicity lipid peroxidation inflammatory damage natural antioxidants Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/13d015f2a73545219127113156347c75
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spelling	oai:doaj.org-article:13d015f2a73545219127113156347c752021-12-02T01:45:52ZEffects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo1178-2013https://doaj.org/article/13d015f2a73545219127113156347c752018-11-01T00:00:00Zhttps://www.dovepress.com/effects-of-quercetin-and-arginine-on-the-nephrotoxicity-and-lipid-pero-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah Al-Mohy, Mohammed Suliman Al-Ayed Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and investigate the potential roles of quercetin (Qur) and arginine (Arg) in mitigating the inflammatory kidney damage and dysfunction and inhibiting the toxicity induced by GNPs in rats.Methods: Kidney function was assessed using various serum biomarkers, including blood urea nitrogen (BUN), uric acid (URIC), and creatinine (CR), while toxicity was evaluated by measuring the biomarkers glutathione (GSH) and malondialdehyde (MDA) in kidney tissues. Results: Administration of GNPs to the rats severely affected the serum kidney biomarkers, as confirmed by the notable increases in BUN, URIC, and CR. Substantial changes in the levels of the biomarkers MDA and GSH in the kidney tissues were also observed, with a reduced level of GSH and elevated MDA activity. The administration of Qur or Arg exerted a protective effect against GNP-induced inflammatory kidney damage and toxicity, but with different responses according to their evaluated normalized values.Conclusion: This study demonstrates the beneficial effects of supplementation with Qur or Arg during the treatment with GNPs, potentially providing a powerful tool for cancer therapy. Keywords: gold nanoparticles, nephrotoxicity, lipid peroxidation, inflammatory damage, natural antioxidantsAbdelhalim MAKQaid HAYAl-Mohy YAl-Ayed MSDove Medical PressarticleGold nanoparticlesnephrotoxicitylipid peroxidationinflammatory damagenatural antioxidantsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7765-7770 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanoparticles nephrotoxicity lipid peroxidation inflammatory damage natural antioxidants Medicine (General) R5-920
spellingShingle	Gold nanoparticles nephrotoxicity lipid peroxidation inflammatory damage natural antioxidants Medicine (General) R5-920 Abdelhalim MAK Qaid HAY Al-Mohy Y Al-Ayed MS Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
description	Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah Al-Mohy, Mohammed Suliman Al-Ayed Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and investigate the potential roles of quercetin (Qur) and arginine (Arg) in mitigating the inflammatory kidney damage and dysfunction and inhibiting the toxicity induced by GNPs in rats.Methods: Kidney function was assessed using various serum biomarkers, including blood urea nitrogen (BUN), uric acid (URIC), and creatinine (CR), while toxicity was evaluated by measuring the biomarkers glutathione (GSH) and malondialdehyde (MDA) in kidney tissues. Results: Administration of GNPs to the rats severely affected the serum kidney biomarkers, as confirmed by the notable increases in BUN, URIC, and CR. Substantial changes in the levels of the biomarkers MDA and GSH in the kidney tissues were also observed, with a reduced level of GSH and elevated MDA activity. The administration of Qur or Arg exerted a protective effect against GNP-induced inflammatory kidney damage and toxicity, but with different responses according to their evaluated normalized values.Conclusion: This study demonstrates the beneficial effects of supplementation with Qur or Arg during the treatment with GNPs, potentially providing a powerful tool for cancer therapy. Keywords: gold nanoparticles, nephrotoxicity, lipid peroxidation, inflammatory damage, natural antioxidants
format	article
author	Abdelhalim MAK Qaid HAY Al-Mohy Y Al-Ayed MS
author_facet	Abdelhalim MAK Qaid HAY Al-Mohy Y Al-Ayed MS
author_sort	Abdelhalim MAK
title	Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
title_short	Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
title_full	Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
title_fullStr	Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
title_full_unstemmed	Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
title_sort	effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/13d015f2a73545219127113156347c75
work_keys_str_mv	AT abdelhalimmak effectsofquercetinandarginineonthenephrotoxicityandlipidperoxidationinducedbygoldnanoparticlesinvivo AT qaidhay effectsofquercetinandarginineonthenephrotoxicityandlipidperoxidationinducedbygoldnanoparticlesinvivo AT almohyy effectsofquercetinandarginineonthenephrotoxicityandlipidperoxidationinducedbygoldnanoparticlesinvivo AT alayedms effectsofquercetinandarginineonthenephrotoxicityandlipidperoxidationinducedbygoldnanoparticlesinvivo
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Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo

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