Super stable water-based magnetic fluid as a dual-mode contrast agent

Early diagnosis of cancer has become one of the effective ways to prevent and treat cancer. At present, magnetic resonance imaging (MRI) diagnosis based on nanosized iron oxide with no toxicity and excellent biocompatibility has attracted much attention. But the poor stability of magnetic fluid (MF)...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li Hongcai, Li Tinghua, Wu Qian, Wang Rui, Hong Ruoyu, Li Yonggang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	mri mf optimum reaction conditions stability dual-model image Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/13d20ea9cc804d7b8987ebe30f889b86
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:13d20ea9cc804d7b8987ebe30f889b86
record_format	dspace
spelling	oai:doaj.org-article:13d20ea9cc804d7b8987ebe30f889b862021-12-05T14:10:58ZSuper stable water-based magnetic fluid as a dual-mode contrast agent2191-909710.1515/ntrev-2021-0068https://doaj.org/article/13d20ea9cc804d7b8987ebe30f889b862021-09-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0068https://doaj.org/toc/2191-9097Early diagnosis of cancer has become one of the effective ways to prevent and treat cancer. At present, magnetic resonance imaging (MRI) diagnosis based on nanosized iron oxide with no toxicity and excellent biocompatibility has attracted much attention. But the poor stability of magnetic fluid (MF) is becoming more and more prominent. In view of the poor stability of MF, the dodecanethiol-poly(methacrylic acid) (DDT-PMAA) as an outer shell was prepared for the MFs (Fe3O4@DDT-PMAA MF) to improve the stability. We also compared the amount of reactants, the ratio of reactants, and the reaction temperature, and finally screened out the best reaction conditions, so as to get more stable products. The stability of the system was studied by visual observation, stability index (I), and magnetic weight change. The results demonstrated that Fe3O4@DDT-PMAA can be stable for more than 60 days. The T 1 mapping image showed that the longitudinal relaxivity (r 1) value was 6.9 mM−1 s−1 (1.5 T, room temperature), which was higher than the commercial contrast agent SHU-555 (r 1 = 2.9 mM−1 s−1), but the transverse relaxivity (r 2) value accounted for 64.48% of the commercial contrast agent Feridex (r 2 = 67.8 mM−1 s−1, 1.5 T, room temperature) because the outermost layer was encapsulated by a polymer. In addition, the imaging effect was more vivid and there was almost no background interference of T 1- and T 2-weighted images in vivo, which indicated that the Fe3O4@DDT-PMAA MF exhibited excellent potential in MRI applications.Li HongcaiLi TinghuaWu QianWang RuiHong RuoyuLi YonggangDe Gruyterarticlemrimfoptimum reaction conditionsstabilitydual-model imageTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 1031-1045 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mri mf optimum reaction conditions stability dual-model image Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	mri mf optimum reaction conditions stability dual-model image Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Li Hongcai Li Tinghua Wu Qian Wang Rui Hong Ruoyu Li Yonggang Super stable water-based magnetic fluid as a dual-mode contrast agent
description	Early diagnosis of cancer has become one of the effective ways to prevent and treat cancer. At present, magnetic resonance imaging (MRI) diagnosis based on nanosized iron oxide with no toxicity and excellent biocompatibility has attracted much attention. But the poor stability of magnetic fluid (MF) is becoming more and more prominent. In view of the poor stability of MF, the dodecanethiol-poly(methacrylic acid) (DDT-PMAA) as an outer shell was prepared for the MFs (Fe3O4@DDT-PMAA MF) to improve the stability. We also compared the amount of reactants, the ratio of reactants, and the reaction temperature, and finally screened out the best reaction conditions, so as to get more stable products. The stability of the system was studied by visual observation, stability index (I), and magnetic weight change. The results demonstrated that Fe3O4@DDT-PMAA can be stable for more than 60 days. The T 1 mapping image showed that the longitudinal relaxivity (r 1) value was 6.9 mM−1 s−1 (1.5 T, room temperature), which was higher than the commercial contrast agent SHU-555 (r 1 = 2.9 mM−1 s−1), but the transverse relaxivity (r 2) value accounted for 64.48% of the commercial contrast agent Feridex (r 2 = 67.8 mM−1 s−1, 1.5 T, room temperature) because the outermost layer was encapsulated by a polymer. In addition, the imaging effect was more vivid and there was almost no background interference of T 1- and T 2-weighted images in vivo, which indicated that the Fe3O4@DDT-PMAA MF exhibited excellent potential in MRI applications.
format	article
author	Li Hongcai Li Tinghua Wu Qian Wang Rui Hong Ruoyu Li Yonggang
author_facet	Li Hongcai Li Tinghua Wu Qian Wang Rui Hong Ruoyu Li Yonggang
author_sort	Li Hongcai
title	Super stable water-based magnetic fluid as a dual-mode contrast agent
title_short	Super stable water-based magnetic fluid as a dual-mode contrast agent
title_full	Super stable water-based magnetic fluid as a dual-mode contrast agent
title_fullStr	Super stable water-based magnetic fluid as a dual-mode contrast agent
title_full_unstemmed	Super stable water-based magnetic fluid as a dual-mode contrast agent
title_sort	super stable water-based magnetic fluid as a dual-mode contrast agent
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/13d20ea9cc804d7b8987ebe30f889b86
work_keys_str_mv	AT lihongcai superstablewaterbasedmagneticfluidasadualmodecontrastagent AT litinghua superstablewaterbasedmagneticfluidasadualmodecontrastagent AT wuqian superstablewaterbasedmagneticfluidasadualmodecontrastagent AT wangrui superstablewaterbasedmagneticfluidasadualmodecontrastagent AT hongruoyu superstablewaterbasedmagneticfluidasadualmodecontrastagent AT liyonggang superstablewaterbasedmagneticfluidasadualmodecontrastagent
_version_	1718371523657465856

Super stable water-based magnetic fluid as a dual-mode contrast agent

Ejemplares similares