Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer

Abstract In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functional...

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Autores principales:	Marco Natuzzi, Coralie Grange, Thomas Gréa, Thomas Brichart, Axel Aigle, Denise Bechet, Benoit Hautefeuille, Eloise Thomas, Jean-Yves Ayoub, Jeanne-Marie Bonnet, Vanessa Louzier, Bernard Allaouchiche, Aymeric Couturier, Alexandra Montembault, Paula Nunes de Oliveira, Laurent David, François Lux, Olivier Tillement
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13d5a4b6be00478b87478b39c155fb62
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spelling	oai:doaj.org-article:13d5a4b6be00478b87478b39c155fb622021-12-02T19:16:14ZFeasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer10.1038/s41598-021-99462-y2045-2322https://doaj.org/article/13d5a4b6be00478b87478b39c155fb622021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99462-yhttps://doaj.org/toc/2045-2322Abstract In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate during hemodialysis. Copper extraction has been evaluated in vitro using an hemodialysis protocol. Feasibility study has been performed on healthy sheep showing no acute toxicity througout the entire dialysis procedure and first insights of metallic extraction even on healthy animals.Marco NatuzziCoralie GrangeThomas GréaThomas BrichartAxel AigleDenise BechetBenoit HautefeuilleEloise ThomasJean-Yves AyoubJeanne-Marie BonnetVanessa LouzierBernard AllaouchicheAymeric CouturierAlexandra MontembaultPaula Nunes de OliveiraLaurent DavidFrançois LuxOlivier TillementNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco Natuzzi Coralie Grange Thomas Gréa Thomas Brichart Axel Aigle Denise Bechet Benoit Hautefeuille Eloise Thomas Jean-Yves Ayoub Jeanne-Marie Bonnet Vanessa Louzier Bernard Allaouchiche Aymeric Couturier Alexandra Montembault Paula Nunes de Oliveira Laurent David François Lux Olivier Tillement Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
description	Abstract In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate during hemodialysis. Copper extraction has been evaluated in vitro using an hemodialysis protocol. Feasibility study has been performed on healthy sheep showing no acute toxicity througout the entire dialysis procedure and first insights of metallic extraction even on healthy animals.
format	article
author	Marco Natuzzi Coralie Grange Thomas Gréa Thomas Brichart Axel Aigle Denise Bechet Benoit Hautefeuille Eloise Thomas Jean-Yves Ayoub Jeanne-Marie Bonnet Vanessa Louzier Bernard Allaouchiche Aymeric Couturier Alexandra Montembault Paula Nunes de Oliveira Laurent David François Lux Olivier Tillement
author_facet	Marco Natuzzi Coralie Grange Thomas Gréa Thomas Brichart Axel Aigle Denise Bechet Benoit Hautefeuille Eloise Thomas Jean-Yves Ayoub Jeanne-Marie Bonnet Vanessa Louzier Bernard Allaouchiche Aymeric Couturier Alexandra Montembault Paula Nunes de Oliveira Laurent David François Lux Olivier Tillement
author_sort	Marco Natuzzi
title	Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
title_short	Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
title_full	Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
title_fullStr	Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
title_full_unstemmed	Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
title_sort	feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13d5a4b6be00478b87478b39c155fb62
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Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer

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