Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1

How the activity of the neuronal Kv3.3 voltage-dependent channel is regulated is unclear. Here, the authors show that the known Kv3.3 channel complex with Hax1, which affects spinal cerebellar ataxia, regulates the enzyme Tank Binding Kinase 1, modulating survival of cerebellar neurons.

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Autores principales:	Yalan Zhang, Luis Varela, Klara Szigeti-Buck, Adam Williams, Milan Stoiljkovic, Matija Šestan-Peša, Jorge Henao-Mejia, Pasquale D’Acunzo, Efrat Levy, Richard A. Flavell, Tamas L. Horvath, Leonard K. Kaczmarek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13d7eef65e4645d8b409edf85235aea3
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spelling	oai:doaj.org-article:13d7eef65e4645d8b409edf85235aea32021-12-02T13:17:59ZCerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-110.1038/s41467-021-22003-82041-1723https://doaj.org/article/13d7eef65e4645d8b409edf85235aea32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22003-8https://doaj.org/toc/2041-1723How the activity of the neuronal Kv3.3 voltage-dependent channel is regulated is unclear. Here, the authors show that the known Kv3.3 channel complex with Hax1, which affects spinal cerebellar ataxia, regulates the enzyme Tank Binding Kinase 1, modulating survival of cerebellar neurons.Yalan ZhangLuis VarelaKlara Szigeti-BuckAdam WilliamsMilan StoiljkovicMatija Šestan-PešaJorge Henao-MejiaPasquale D’AcunzoEfrat LevyRichard A. FlavellTamas L. HorvathLeonard K. KaczmarekNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yalan Zhang Luis Varela Klara Szigeti-Buck Adam Williams Milan Stoiljkovic Matija Šestan-Peša Jorge Henao-Mejia Pasquale D’Acunzo Efrat Levy Richard A. Flavell Tamas L. Horvath Leonard K. Kaczmarek Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
description	How the activity of the neuronal Kv3.3 voltage-dependent channel is regulated is unclear. Here, the authors show that the known Kv3.3 channel complex with Hax1, which affects spinal cerebellar ataxia, regulates the enzyme Tank Binding Kinase 1, modulating survival of cerebellar neurons.
format	article
author	Yalan Zhang Luis Varela Klara Szigeti-Buck Adam Williams Milan Stoiljkovic Matija Šestan-Peša Jorge Henao-Mejia Pasquale D’Acunzo Efrat Levy Richard A. Flavell Tamas L. Horvath Leonard K. Kaczmarek
author_facet	Yalan Zhang Luis Varela Klara Szigeti-Buck Adam Williams Milan Stoiljkovic Matija Šestan-Peša Jorge Henao-Mejia Pasquale D’Acunzo Efrat Levy Richard A. Flavell Tamas L. Horvath Leonard K. Kaczmarek
author_sort	Yalan Zhang
title	Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
title_short	Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
title_full	Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
title_fullStr	Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
title_full_unstemmed	Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
title_sort	cerebellar kv3.3 potassium channels activate tank-binding kinase 1 to regulate trafficking of the cell survival protein hax-1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13d7eef65e4645d8b409edf85235aea3
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Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1

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