A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state an...

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Autores principales:	Irene Schiano Lomoriello, Giovanni Giangreco, Claudia Iavarone, Chiara Tordonato, Giusi Caldieri, Gaetana Serio, Stefano Confalonieri, Stefano Freddi, Fabrizio Bianchi, Stefania Pirroni, Giovanni Bertalot, Giuseppe Viale, Davide Disalvatore, Daniela Tosoni, Maria Grazia Malabarba, Andrea Disanza, Giorgio Scita, Salvatore Pece, Brian K. Pilcher, Manuela Vecchi, Sara Sigismund, Pier Paolo Di Fiore
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c693
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id	oai:doaj.org-article:13d80ead99db4faeaae47bea7bd4c693
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spelling	oai:doaj.org-article:13d80ead99db4faeaae47bea7bd4c6932021-12-02T17:23:50ZA self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior10.1038/s41467-020-16836-y2041-1723https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c6932020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16836-yhttps://doaj.org/toc/2041-1723It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.Irene Schiano LomorielloGiovanni GiangrecoClaudia IavaroneChiara TordonatoGiusi CaldieriGaetana SerioStefano ConfalonieriStefano FreddiFabrizio BianchiStefania PirroniGiovanni BertalotGiuseppe VialeDavide DisalvatoreDaniela TosoniMaria Grazia MalabarbaAndrea DisanzaGiorgio ScitaSalvatore PeceBrian K. PilcherManuela VecchiSara SigismundPier Paolo Di FioreNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irene Schiano Lomoriello Giovanni Giangreco Claudia Iavarone Chiara Tordonato Giusi Caldieri Gaetana Serio Stefano Confalonieri Stefano Freddi Fabrizio Bianchi Stefania Pirroni Giovanni Bertalot Giuseppe Viale Davide Disalvatore Daniela Tosoni Maria Grazia Malabarba Andrea Disanza Giorgio Scita Salvatore Pece Brian K. Pilcher Manuela Vecchi Sara Sigismund Pier Paolo Di Fiore A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
description	It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.
format	article
author	Irene Schiano Lomoriello Giovanni Giangreco Claudia Iavarone Chiara Tordonato Giusi Caldieri Gaetana Serio Stefano Confalonieri Stefano Freddi Fabrizio Bianchi Stefania Pirroni Giovanni Bertalot Giuseppe Viale Davide Disalvatore Daniela Tosoni Maria Grazia Malabarba Andrea Disanza Giorgio Scita Salvatore Pece Brian K. Pilcher Manuela Vecchi Sara Sigismund Pier Paolo Di Fiore
author_facet	Irene Schiano Lomoriello Giovanni Giangreco Claudia Iavarone Chiara Tordonato Giusi Caldieri Gaetana Serio Stefano Confalonieri Stefano Freddi Fabrizio Bianchi Stefania Pirroni Giovanni Bertalot Giuseppe Viale Davide Disalvatore Daniela Tosoni Maria Grazia Malabarba Andrea Disanza Giorgio Scita Salvatore Pece Brian K. Pilcher Manuela Vecchi Sara Sigismund Pier Paolo Di Fiore
author_sort	Irene Schiano Lomoriello
title	A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
title_short	A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
title_full	A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
title_fullStr	A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
title_full_unstemmed	A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
title_sort	self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c693
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A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

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