Modelling the microenvironment of the most aggressive brain tumours for preclinical studies

Preclinical and clinical cancer studies use unrepresentative tumour models that do not properly simulate the intricate pathobiology of the human tumour and its complex microenvironment. This is of critical importance for the brain tumour glioblastoma (GBM), one of the most malignant cancers, which a...

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Autores principales:	Juš Žavbi, Barbara Breznik
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Brain cancer Glioblastoma Tumour microenvironment Tumour models Cancer stem cells Therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/13d8abdaf9e9438f97142dd7ee21fff8
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spelling	oai:doaj.org-article:13d8abdaf9e9438f97142dd7ee21fff82021-11-28T04:40:11ZModelling the microenvironment of the most aggressive brain tumours for preclinical studies2667-394010.1016/j.adcanc.2021.100017https://doaj.org/article/13d8abdaf9e9438f97142dd7ee21fff82021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667394021000174https://doaj.org/toc/2667-3940Preclinical and clinical cancer studies use unrepresentative tumour models that do not properly simulate the intricate pathobiology of the human tumour and its complex microenvironment. This is of critical importance for the brain tumour glioblastoma (GBM), one of the most malignant cancers, which almost always relapses despite treatment. Due to the intertumoral and intratumoral heterogeneity of GBM, it is highly resistant to conventional treatment with radiotherapy and chemotherapy. In this review, we describe the heterogeneity of GBM and the unique microenvironment of brain tumours as well as their importance for GBM progression and to set up clinically relevant GBM models for successful preclinical research and drug screening. A combination of cancer cells, cancer stem cells, and cancer-associated cells create an intricate and diverse tumour microenvironment. GBM is very adept at recruiting healthy cells to support itself. The function of these cancer-associated cells varies in different niches, but they all share the common function of promoting tumour growth and spread. Glioblastoma stem cells are one of the central components of GBM treatment resistance, invasiveness, and cancer stem cell niche relationships. All of these aspects are critical when selecting and designing preclinical GBM models.Juš ŽavbiBarbara BreznikElsevierarticleBrain cancerGlioblastomaTumour microenvironmentTumour modelsCancer stem cellsTherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENAdvances in Cancer Biology - Metastasis, Vol 3, Iss , Pp 100017- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain cancer Glioblastoma Tumour microenvironment Tumour models Cancer stem cells Therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Brain cancer Glioblastoma Tumour microenvironment Tumour models Cancer stem cells Therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Juš Žavbi Barbara Breznik Modelling the microenvironment of the most aggressive brain tumours for preclinical studies
description	Preclinical and clinical cancer studies use unrepresentative tumour models that do not properly simulate the intricate pathobiology of the human tumour and its complex microenvironment. This is of critical importance for the brain tumour glioblastoma (GBM), one of the most malignant cancers, which almost always relapses despite treatment. Due to the intertumoral and intratumoral heterogeneity of GBM, it is highly resistant to conventional treatment with radiotherapy and chemotherapy. In this review, we describe the heterogeneity of GBM and the unique microenvironment of brain tumours as well as their importance for GBM progression and to set up clinically relevant GBM models for successful preclinical research and drug screening. A combination of cancer cells, cancer stem cells, and cancer-associated cells create an intricate and diverse tumour microenvironment. GBM is very adept at recruiting healthy cells to support itself. The function of these cancer-associated cells varies in different niches, but they all share the common function of promoting tumour growth and spread. Glioblastoma stem cells are one of the central components of GBM treatment resistance, invasiveness, and cancer stem cell niche relationships. All of these aspects are critical when selecting and designing preclinical GBM models.
format	article
author	Juš Žavbi Barbara Breznik
author_facet	Juš Žavbi Barbara Breznik
author_sort	Juš Žavbi
title	Modelling the microenvironment of the most aggressive brain tumours for preclinical studies
title_short	Modelling the microenvironment of the most aggressive brain tumours for preclinical studies
title_full	Modelling the microenvironment of the most aggressive brain tumours for preclinical studies
title_fullStr	Modelling the microenvironment of the most aggressive brain tumours for preclinical studies
title_full_unstemmed	Modelling the microenvironment of the most aggressive brain tumours for preclinical studies
title_sort	modelling the microenvironment of the most aggressive brain tumours for preclinical studies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/13d8abdaf9e9438f97142dd7ee21fff8
work_keys_str_mv	AT juszavbi modellingthemicroenvironmentofthemostaggressivebraintumoursforpreclinicalstudies AT barbarabreznik modellingthemicroenvironmentofthemostaggressivebraintumoursforpreclinicalstudies
_version_	1718408241209147392

Modelling the microenvironment of the most aggressive brain tumours for preclinical studies

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