Computationally efficient model of myocardial electromechanics for multiscale simulations.

A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the...

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Autores principales:	Fyodor Syomin, Anna Osepyan, Andrey Tsaturyan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13d8ce0222c0451a94fb9ce25507f389
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spelling	oai:doaj.org-article:13d8ce0222c0451a94fb9ce25507f3892021-12-02T20:06:31ZComputationally efficient model of myocardial electromechanics for multiscale simulations.1932-620310.1371/journal.pone.0255027https://doaj.org/article/13d8ce0222c0451a94fb9ce25507f3892021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255027https://doaj.org/toc/1932-6203A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the propagation velocity of the action potential, are also accounted for. The model reproduces changes in the twitch amplitude and Ca2+-transients upon changes in muscle strain including the slow response. The model also reproduces the Bowditch effect and changes in the twitch amplitude and duration upon changes in the interstimulus interval, including accelerated relaxation at high stimulation frequency. Special efforts were taken to reduce the stiffness of the differential equations of the model. As a result, the equations can be integrated numerically with a relatively high time step making the model suitable for multiscale simulation of the human heart and allowing one to study the impact of myocardial mechanics on arrhythmias.Fyodor SyominAnna OsepyanAndrey TsaturyanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255027 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fyodor Syomin Anna Osepyan Andrey Tsaturyan Computationally efficient model of myocardial electromechanics for multiscale simulations.
description	A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the propagation velocity of the action potential, are also accounted for. The model reproduces changes in the twitch amplitude and Ca2+-transients upon changes in muscle strain including the slow response. The model also reproduces the Bowditch effect and changes in the twitch amplitude and duration upon changes in the interstimulus interval, including accelerated relaxation at high stimulation frequency. Special efforts were taken to reduce the stiffness of the differential equations of the model. As a result, the equations can be integrated numerically with a relatively high time step making the model suitable for multiscale simulation of the human heart and allowing one to study the impact of myocardial mechanics on arrhythmias.
format	article
author	Fyodor Syomin Anna Osepyan Andrey Tsaturyan
author_facet	Fyodor Syomin Anna Osepyan Andrey Tsaturyan
author_sort	Fyodor Syomin
title	Computationally efficient model of myocardial electromechanics for multiscale simulations.
title_short	Computationally efficient model of myocardial electromechanics for multiscale simulations.
title_full	Computationally efficient model of myocardial electromechanics for multiscale simulations.
title_fullStr	Computationally efficient model of myocardial electromechanics for multiscale simulations.
title_full_unstemmed	Computationally efficient model of myocardial electromechanics for multiscale simulations.
title_sort	computationally efficient model of myocardial electromechanics for multiscale simulations.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/13d8ce0222c0451a94fb9ce25507f389
work_keys_str_mv	AT fyodorsyomin computationallyefficientmodelofmyocardialelectromechanicsformultiscalesimulations AT annaosepyan computationallyefficientmodelofmyocardialelectromechanicsformultiscalesimulations AT andreytsaturyan computationallyefficientmodelofmyocardialelectromechanicsformultiscalesimulations
_version_	1718375345898389504

Computationally efficient model of myocardial electromechanics for multiscale simulations.

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