Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synthesis and markedly alters the heart phosphoproteome...

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Autores principales:	Jacquelyn M. Walejko, Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, Stephani Page, Stephan van Vliet, Olga Ilkayeva, Michael J. Muehlbauer, Matthew W. Carson, Joseph T. Brozinick, Craig D. Hammond, Ruth E. Gimeno, M. Arthur Moseley, Shingo Kajimura, Charles A. Gersbach, Christopher B. Newgard, Phillip J. White, Robert W. McGarrah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13e6e6480fe7436f81d6416509424af3
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spelling	oai:doaj.org-article:13e6e6480fe7436f81d6416509424af32021-12-02T17:03:35ZBranched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart10.1038/s41467-021-21962-22041-1723https://doaj.org/article/13e6e6480fe7436f81d6416509424af32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21962-2https://doaj.org/toc/2041-1723Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synthesis and markedly alters the heart phosphoproteome.Jacquelyn M. WalejkoBridgette A. ChristopherScott B. CrownGuo-Fang ZhangAdrian Pickar-OliverTakeshi YoneshiroMatthew W. FosterStephani PageStephan van VlietOlga IlkayevaMichael J. MuehlbauerMatthew W. CarsonJoseph T. BrozinickCraig D. HammondRuth E. GimenoM. Arthur MoseleyShingo KajimuraCharles A. GersbachChristopher B. NewgardPhillip J. WhiteRobert W. McGarrahNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacquelyn M. Walejko Bridgette A. Christopher Scott B. Crown Guo-Fang Zhang Adrian Pickar-Oliver Takeshi Yoneshiro Matthew W. Foster Stephani Page Stephan van Vliet Olga Ilkayeva Michael J. Muehlbauer Matthew W. Carson Joseph T. Brozinick Craig D. Hammond Ruth E. Gimeno M. Arthur Moseley Shingo Kajimura Charles A. Gersbach Christopher B. Newgard Phillip J. White Robert W. McGarrah Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
description	Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synthesis and markedly alters the heart phosphoproteome.
format	article
author	Jacquelyn M. Walejko Bridgette A. Christopher Scott B. Crown Guo-Fang Zhang Adrian Pickar-Oliver Takeshi Yoneshiro Matthew W. Foster Stephani Page Stephan van Vliet Olga Ilkayeva Michael J. Muehlbauer Matthew W. Carson Joseph T. Brozinick Craig D. Hammond Ruth E. Gimeno M. Arthur Moseley Shingo Kajimura Charles A. Gersbach Christopher B. Newgard Phillip J. White Robert W. McGarrah
author_facet	Jacquelyn M. Walejko Bridgette A. Christopher Scott B. Crown Guo-Fang Zhang Adrian Pickar-Oliver Takeshi Yoneshiro Matthew W. Foster Stephani Page Stephan van Vliet Olga Ilkayeva Michael J. Muehlbauer Matthew W. Carson Joseph T. Brozinick Craig D. Hammond Ruth E. Gimeno M. Arthur Moseley Shingo Kajimura Charles A. Gersbach Christopher B. Newgard Phillip J. White Robert W. McGarrah
author_sort	Jacquelyn M. Walejko
title	Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
title_short	Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
title_full	Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
title_fullStr	Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
title_full_unstemmed	Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
title_sort	branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13e6e6480fe7436f81d6416509424af3
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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

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