Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre

Objective: To comparatively evaluate ICU requirement, length of stay, and mortality between single-dose vaccinated and non-vaccinated hospitalized COVID-19 patients. Design: A retrospective observational study was carried out in a tertiary care hospital in western Indian, from April 1 to June 30, 20...

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Autores principales:	Anuja Desai, Parth Desai, Jigar Mehta, Wasimahmed Sachora, Neeraj Bharti, Tushar Patel, Kalpesh Sukhwani, Ankita Jain, Dipesh Sorathiya, Vivek Nanda, Parin Mehta, Adit Desai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 vaccination SARS-CoV-2 infection ChAdOx1 nCoV-19 vaccine vaccine hesitancy Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/13e7817739154e629317197a1c0675da
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spelling	oai:doaj.org-article:13e7817739154e629317197a1c0675da2021-11-14T04:31:16ZMeasuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre1201-971210.1016/j.ijid.2021.10.032https://doaj.org/article/13e7817739154e629317197a1c0675da2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008195https://doaj.org/toc/1201-9712Objective: To comparatively evaluate ICU requirement, length of stay, and mortality between single-dose vaccinated and non-vaccinated hospitalized COVID-19 patients. Design: A retrospective observational study was carried out in a tertiary care hospital in western Indian, from April 1 to June 30, 2021. Results: Of the 569 patients who fulfilled the eligibility criteria and were enrolled in the study, 137 (24.08%) patients had received a single dose of ChAdOx1 nCoV-19 vaccine, while 432 (75.92%) patients had not received any form of vaccination. The overall length of stay in hospital was similar for both groups; however, a significant difference was seen in length of stay in the ward and in the ICU. Vaccinated patients were admitted to the ward for 6.21 ± 3.204 days, while non-vaccinated patients were admitted for 5.56 ± 4.55 days (p < 0.001). The mean length of ICU stay for the 21 vaccinated patients requiring intensive care was 4.47 ± 2.3 days, while that for the 145 non-vaccinated patients was 6.29 ± 2.19 days (p < 0.001). Mortality was observed in four patients in the vaccinated group and in 95 patients in the non-vaccinated group. Conclusion: A single dose of ChAdOx1 nCoV-19 vaccine was associated with a significantly lower severity of SARS-CoV-2 infection compared with no vaccination.Anuja DesaiParth DesaiJigar MehtaWasimahmed SachoraNeeraj BhartiTushar PatelKalpesh SukhwaniAnkita JainDipesh SorathiyaVivek NandaParin MehtaAdit DesaiElsevierarticleCOVID-19vaccinationSARS-CoV-2 infectionChAdOx1 nCoV-19 vaccinevaccine hesitancyInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 282-287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 vaccination SARS-CoV-2 infection ChAdOx1 nCoV-19 vaccine vaccine hesitancy Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 vaccination SARS-CoV-2 infection ChAdOx1 nCoV-19 vaccine vaccine hesitancy Infectious and parasitic diseases RC109-216 Anuja Desai Parth Desai Jigar Mehta Wasimahmed Sachora Neeraj Bharti Tushar Patel Kalpesh Sukhwani Ankita Jain Dipesh Sorathiya Vivek Nanda Parin Mehta Adit Desai Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre
description	Objective: To comparatively evaluate ICU requirement, length of stay, and mortality between single-dose vaccinated and non-vaccinated hospitalized COVID-19 patients. Design: A retrospective observational study was carried out in a tertiary care hospital in western Indian, from April 1 to June 30, 2021. Results: Of the 569 patients who fulfilled the eligibility criteria and were enrolled in the study, 137 (24.08%) patients had received a single dose of ChAdOx1 nCoV-19 vaccine, while 432 (75.92%) patients had not received any form of vaccination. The overall length of stay in hospital was similar for both groups; however, a significant difference was seen in length of stay in the ward and in the ICU. Vaccinated patients were admitted to the ward for 6.21 ± 3.204 days, while non-vaccinated patients were admitted for 5.56 ± 4.55 days (p < 0.001). The mean length of ICU stay for the 21 vaccinated patients requiring intensive care was 4.47 ± 2.3 days, while that for the 145 non-vaccinated patients was 6.29 ± 2.19 days (p < 0.001). Mortality was observed in four patients in the vaccinated group and in 95 patients in the non-vaccinated group. Conclusion: A single dose of ChAdOx1 nCoV-19 vaccine was associated with a significantly lower severity of SARS-CoV-2 infection compared with no vaccination.
format	article
author	Anuja Desai Parth Desai Jigar Mehta Wasimahmed Sachora Neeraj Bharti Tushar Patel Kalpesh Sukhwani Ankita Jain Dipesh Sorathiya Vivek Nanda Parin Mehta Adit Desai
author_facet	Anuja Desai Parth Desai Jigar Mehta Wasimahmed Sachora Neeraj Bharti Tushar Patel Kalpesh Sukhwani Ankita Jain Dipesh Sorathiya Vivek Nanda Parin Mehta Adit Desai
author_sort	Anuja Desai
title	Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre
title_short	Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre
title_full	Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre
title_fullStr	Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre
title_full_unstemmed	Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre
title_sort	measuring the impact of a single dose of chadox1 ncov-19 (recombinant) coronavirus vaccine on hospital stay, icu requirement, and mortality outcome in a tertiary care centre
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/13e7817739154e629317197a1c0675da
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Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre

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