Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity

Sensory organs: drug induces nerve growth for ectopic eye transplant A migraine drug that modulates neurotransmitter signaling can boost the neural connections of eyes grafted onto tadpoles to enhance vision. Michael Levin and colleagues from Tufts University in Medford, MA, USA, built on previous w...

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Autores principales:	Douglas J. Blackiston, Khanh Vien, Michael Levin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/13e8629003d1490690eead37df810364
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spelling	oai:doaj.org-article:13e8629003d1490690eead37df8103642021-12-02T16:05:45ZSerotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity10.1038/s41536-017-0012-52057-3995https://doaj.org/article/13e8629003d1490690eead37df8103642017-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0012-5https://doaj.org/toc/2057-3995Sensory organs: drug induces nerve growth for ectopic eye transplant A migraine drug that modulates neurotransmitter signaling can boost the neural connections of eyes grafted onto tadpoles to enhance vision. Michael Levin and colleagues from Tufts University in Medford, MA, USA, built on previous work from their lab showing that eyes could be attached along the body axis of blind tadpoles, allowing the developing frogs to distinguish between light and dark. Following the surgery, the researchers have now added the drug zolmitriptan, an activator of serotonin receptors, and the tadpoles formed many more neural connections that sprouted from their ectopic eyes. These animals performed better in visual-learning and pattern-movement tests than control tadpoles that did not get the drug. The findings suggest that drugs used to treat neurological and psychiatric diseases could be repurposed to augment the innervation, integration, and function of organs transplanted in regenerative therapies.Douglas J. BlackistonKhanh VienMichael LevinNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Douglas J. Blackiston Khanh Vien Michael Levin Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
description	Sensory organs: drug induces nerve growth for ectopic eye transplant A migraine drug that modulates neurotransmitter signaling can boost the neural connections of eyes grafted onto tadpoles to enhance vision. Michael Levin and colleagues from Tufts University in Medford, MA, USA, built on previous work from their lab showing that eyes could be attached along the body axis of blind tadpoles, allowing the developing frogs to distinguish between light and dark. Following the surgery, the researchers have now added the drug zolmitriptan, an activator of serotonin receptors, and the tadpoles formed many more neural connections that sprouted from their ectopic eyes. These animals performed better in visual-learning and pattern-movement tests than control tadpoles that did not get the drug. The findings suggest that drugs used to treat neurological and psychiatric diseases could be repurposed to augment the innervation, integration, and function of organs transplanted in regenerative therapies.
format	article
author	Douglas J. Blackiston Khanh Vien Michael Levin
author_facet	Douglas J. Blackiston Khanh Vien Michael Levin
author_sort	Douglas J. Blackiston
title	Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
title_short	Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
title_full	Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
title_fullStr	Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
title_full_unstemmed	Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
title_sort	serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/13e8629003d1490690eead37df810364
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_version_	1718385130801725440

Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity

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