BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

BRCA2 mutations promote tumour formation while also paradoxically causing cell lethality. Here the authors generate conditional BRCA2 loss in a non-transformed human mammary cell line and see increased replication stress due to under-replication of DNA.

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Autores principales:	Weiran Feng, Maria Jasin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13ea0e66ca9041bb8737afe82abbcbd9
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spelling	oai:doaj.org-article:13ea0e66ca9041bb8737afe82abbcbd92021-12-02T14:42:37ZBRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination10.1038/s41467-017-00634-02041-1723https://doaj.org/article/13ea0e66ca9041bb8737afe82abbcbd92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00634-0https://doaj.org/toc/2041-1723BRCA2 mutations promote tumour formation while also paradoxically causing cell lethality. Here the authors generate conditional BRCA2 loss in a non-transformed human mammary cell line and see increased replication stress due to under-replication of DNA.Weiran FengMaria JasinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiran Feng Maria Jasin BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
description	BRCA2 mutations promote tumour formation while also paradoxically causing cell lethality. Here the authors generate conditional BRCA2 loss in a non-transformed human mammary cell line and see increased replication stress due to under-replication of DNA.
format	article
author	Weiran Feng Maria Jasin
author_facet	Weiran Feng Maria Jasin
author_sort	Weiran Feng
title	BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
title_short	BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
title_full	BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
title_fullStr	BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
title_full_unstemmed	BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
title_sort	brca2 suppresses replication stress-induced mitotic and g1 abnormalities through homologous recombination
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/13ea0e66ca9041bb8737afe82abbcbd9
work_keys_str_mv	AT weiranfeng brca2suppressesreplicationstressinducedmitoticandg1abnormalitiesthroughhomologousrecombination AT mariajasin brca2suppressesreplicationstressinducedmitoticandg1abnormalitiesthroughhomologousrecombination
_version_	1718389613544865792

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

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