Types of neural guides and using nanotechnology for peripheral nerve reconstruction

Esmaeil Biazar1, MT Khorasani2, Naser Montazeri1, Khalil Pourshamsian1, Morteza Daliri3, Mostafa Rezaei T4, Mahmoud Jabarvand B5, Ahad Khoshzaban5, Saeed Heidari K4,5, Mostafa Jafarpour6, Ziba Roviemiab71Department of Chemistry, Islamic Azad University-Tonekabon Branch, Iran; 2Biomaterial Department...

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Autores principales:	Esmaeil Biazar, MT Khorasani, Naser Montazeri, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/13eeaca7504b45a19e0891152ec7aacd
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spelling	oai:doaj.org-article:13eeaca7504b45a19e0891152ec7aacd2021-12-02T01:15:59ZTypes of neural guides and using nanotechnology for peripheral nerve reconstruction1176-91141178-2013https://doaj.org/article/13eeaca7504b45a19e0891152ec7aacd2010-10-01T00:00:00Zhttp://www.dovepress.com/types-of-neural-guides-and-using-nanotechnology-for-peripheral-nerve-r-a5478https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Esmaeil Biazar1, MT Khorasani2, Naser Montazeri1, Khalil Pourshamsian1, Morteza Daliri3, Mostafa Rezaei T4, Mahmoud Jabarvand B5, Ahad Khoshzaban5, Saeed Heidari K4,5, Mostafa Jafarpour6, Ziba Roviemiab71Department of Chemistry, Islamic Azad University-Tonekabon Branch, Iran; 2Biomaterial Department of Iran Polymer and Petrochemical Institute, Tehran, Iran; 3National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran; 4Proteomics Research Center, Faculty of Paramedical Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran; 5Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Microbiology, Islamic Azad University-Tonekabon Branch, Iran; 7Biomedical Engineering Faculty, Islamic Azad University-Science and Research Branch, Tehran, IranAbstract: Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Different methods, such as conventional allograft procedures and use of biologic tubes present problems when used for damaged peripheral nerve reconstruction. Designed scaffolds comprised of natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and nonabsorbable synthetic and natural polymers with unique characteristics can be an appropriate solution to repair damaged nerve tissues. Polymeric nanofibrous scaffolds with properties similar to neural structures can be more effective in the reconstruction process. Better cell adhesion and migration, more guiding of axons, and structural features, such as porosity, provide a clearer role for nanofibers in the restoration of neural tissues. In this paper, basic concepts of peripheral nerve injury, types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application in peripheral nerve reconstruction are reviewed.Keywords: peripheral nerve injuries, nerve reconstruction, neural guide, nanofibers&nbsp; Esmaeil BiazarMT KhorasaniNaser Montazeriet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 839-852 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Esmaeil Biazar MT Khorasani Naser Montazeri et al Types of neural guides and using nanotechnology for peripheral nerve reconstruction
description	Esmaeil Biazar1, MT Khorasani2, Naser Montazeri1, Khalil Pourshamsian1, Morteza Daliri3, Mostafa Rezaei T4, Mahmoud Jabarvand B5, Ahad Khoshzaban5, Saeed Heidari K4,5, Mostafa Jafarpour6, Ziba Roviemiab71Department of Chemistry, Islamic Azad University-Tonekabon Branch, Iran; 2Biomaterial Department of Iran Polymer and Petrochemical Institute, Tehran, Iran; 3National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran; 4Proteomics Research Center, Faculty of Paramedical Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran; 5Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Microbiology, Islamic Azad University-Tonekabon Branch, Iran; 7Biomedical Engineering Faculty, Islamic Azad University-Science and Research Branch, Tehran, IranAbstract: Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Different methods, such as conventional allograft procedures and use of biologic tubes present problems when used for damaged peripheral nerve reconstruction. Designed scaffolds comprised of natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and nonabsorbable synthetic and natural polymers with unique characteristics can be an appropriate solution to repair damaged nerve tissues. Polymeric nanofibrous scaffolds with properties similar to neural structures can be more effective in the reconstruction process. Better cell adhesion and migration, more guiding of axons, and structural features, such as porosity, provide a clearer role for nanofibers in the restoration of neural tissues. In this paper, basic concepts of peripheral nerve injury, types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application in peripheral nerve reconstruction are reviewed.Keywords: peripheral nerve injuries, nerve reconstruction, neural guide, nanofibers&nbsp;
format	article
author	Esmaeil Biazar MT Khorasani Naser Montazeri et al
author_facet	Esmaeil Biazar MT Khorasani Naser Montazeri et al
author_sort	Esmaeil Biazar
title	Types of neural guides and using nanotechnology for peripheral nerve reconstruction
title_short	Types of neural guides and using nanotechnology for peripheral nerve reconstruction
title_full	Types of neural guides and using nanotechnology for peripheral nerve reconstruction
title_fullStr	Types of neural guides and using nanotechnology for peripheral nerve reconstruction
title_full_unstemmed	Types of neural guides and using nanotechnology for peripheral nerve reconstruction
title_sort	types of neural guides and using nanotechnology for peripheral nerve reconstruction
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/13eeaca7504b45a19e0891152ec7aacd
work_keys_str_mv	AT esmaeilbiazar typesofneuralguidesandusingnanotechnologyforperipheralnervereconstruction AT mtkhorasani typesofneuralguidesandusingnanotechnologyforperipheralnervereconstruction AT nasermontazeri typesofneuralguidesandusingnanotechnologyforperipheralnervereconstruction AT etal typesofneuralguidesandusingnanotechnologyforperipheralnervereconstruction
_version_	1718403181365428224

Types of neural guides and using nanotechnology for peripheral nerve reconstruction

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