High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy

Abstract Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could signific...

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Bibliographic Details
Main Authors: A. M. Kivelä, J. Huusko, E. Gurzeler, A. Laine, M. H. Dijkstra, G. Dragneva, C. B. F. Andersen, S. K. Moestrup, S. Ylä-Herttuala
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/13eec640ea744d0e8b268a995fb998d0
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