Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation

The incorporation of cells into tissue engineering scaffolds can be a major challenge. Here, the authors report on anchoring thrombin to cell membranes for the in situ formation of fibrin scaffolds around the modified cells, demonstrate scaffold formation in vitro and show cell survival in vivo.

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Autores principales:	Robert C. Deller, Thomas Richardson, Rebecca Richardson, Laura Bevan, Ioannis Zampetakis, Fabrizio Scarpa, Adam W. Perriman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13f3fdf2fed94bc387a56ee953822a19
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id	oai:doaj.org-article:13f3fdf2fed94bc387a56ee953822a19
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spelling	oai:doaj.org-article:13f3fdf2fed94bc387a56ee953822a192021-12-02T17:02:15ZArtificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation10.1038/s41467-019-09763-02041-1723https://doaj.org/article/13f3fdf2fed94bc387a56ee953822a192019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09763-0https://doaj.org/toc/2041-1723The incorporation of cells into tissue engineering scaffolds can be a major challenge. Here, the authors report on anchoring thrombin to cell membranes for the in situ formation of fibrin scaffolds around the modified cells, demonstrate scaffold formation in vitro and show cell survival in vivo.Robert C. DellerThomas RichardsonRebecca RichardsonLaura BevanIoannis ZampetakisFabrizio ScarpaAdam W. PerrimanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert C. Deller Thomas Richardson Rebecca Richardson Laura Bevan Ioannis Zampetakis Fabrizio Scarpa Adam W. Perriman Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
description	The incorporation of cells into tissue engineering scaffolds can be a major challenge. Here, the authors report on anchoring thrombin to cell membranes for the in situ formation of fibrin scaffolds around the modified cells, demonstrate scaffold formation in vitro and show cell survival in vivo.
format	article
author	Robert C. Deller Thomas Richardson Rebecca Richardson Laura Bevan Ioannis Zampetakis Fabrizio Scarpa Adam W. Perriman
author_facet	Robert C. Deller Thomas Richardson Rebecca Richardson Laura Bevan Ioannis Zampetakis Fabrizio Scarpa Adam W. Perriman
author_sort	Robert C. Deller
title	Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
title_short	Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
title_full	Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
title_fullStr	Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
title_full_unstemmed	Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
title_sort	artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/13f3fdf2fed94bc387a56ee953822a19
work_keys_str_mv	AT robertcdeller artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation AT thomasrichardson artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation AT rebeccarichardson artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation AT laurabevan artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation AT ioanniszampetakis artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation AT fabrizioscarpa artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation AT adamwperriman artificialcellmembranebindingthrombinconstructsdriveinsitufibrinhydrogelformation
_version_	1718381892157308928

Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation

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