Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation

The incorporation of cells into tissue engineering scaffolds can be a major challenge. Here, the authors report on anchoring thrombin to cell membranes for the in situ formation of fibrin scaffolds around the modified cells, demonstrate scaffold formation in vitro and show cell survival in vivo.

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Auteurs principaux: Robert C. Deller, Thomas Richardson, Rebecca Richardson, Laura Bevan, Ioannis Zampetakis, Fabrizio Scarpa, Adam W. Perriman
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
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Accès en ligne:https://doaj.org/article/13f3fdf2fed94bc387a56ee953822a19
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