Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates proton sensitivity and contributes to the Ca2+ bloc...

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Autores principales:	Zhicheng Zuo, Rachel N. Smith, Zhenglan Chen, Amruta S. Agharkar, Heather D. Snell, Renqi Huang, Jin Liu, Eric B. Gonzales
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13f55aaea8244e21bacd420c63712ecc
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spelling	oai:doaj.org-article:13f55aaea8244e21bacd420c63712ecc2021-12-02T16:56:54ZIdentification of a unique Ca2+-binding site in rat acid-sensing ion channel 310.1038/s41467-018-04424-02041-1723https://doaj.org/article/13f55aaea8244e21bacd420c63712ecc2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04424-0https://doaj.org/toc/2041-1723Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates proton sensitivity and contributes to the Ca2+ block.Zhicheng ZuoRachel N. SmithZhenglan ChenAmruta S. AgharkarHeather D. SnellRenqi HuangJin LiuEric B. GonzalesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhicheng Zuo Rachel N. Smith Zhenglan Chen Amruta S. Agharkar Heather D. Snell Renqi Huang Jin Liu Eric B. Gonzales Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
description	Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates proton sensitivity and contributes to the Ca2+ block.
format	article
author	Zhicheng Zuo Rachel N. Smith Zhenglan Chen Amruta S. Agharkar Heather D. Snell Renqi Huang Jin Liu Eric B. Gonzales
author_facet	Zhicheng Zuo Rachel N. Smith Zhenglan Chen Amruta S. Agharkar Heather D. Snell Renqi Huang Jin Liu Eric B. Gonzales
author_sort	Zhicheng Zuo
title	Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
title_short	Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
title_full	Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
title_fullStr	Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
title_full_unstemmed	Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
title_sort	identification of a unique ca2+-binding site in rat acid-sensing ion channel 3
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/13f55aaea8244e21bacd420c63712ecc
work_keys_str_mv	AT zhichengzuo identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT rachelnsmith identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT zhenglanchen identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT amrutasagharkar identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT heatherdsnell identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT renqihuang identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT jinliu identificationofauniqueca2bindingsiteinratacidsensingionchannel3 AT ericbgonzales identificationofauniqueca2bindingsiteinratacidsensingionchannel3
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Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

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