Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates proton sensitivity and contributes to the Ca2+ bloc...

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Autores principales: Zhicheng Zuo, Rachel N. Smith, Zhenglan Chen, Amruta S. Agharkar, Heather D. Snell, Renqi Huang, Jin Liu, Eric B. Gonzales
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/13f55aaea8244e21bacd420c63712ecc
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