Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium

Atractyloside (ATR) may cause severe liver and kidney damage. However, there is a lack of information about levels of ATR in parts of Xanthium strumarium and the concentrations and kinetics of ATR in the serum. In this study, we determined atractyloside levels in Xanthium strumarium parts, its seru...

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Autores principales:	Yasin OZTURK, Zeliha KESKIN, Sadettin TANYILDIZI, Burcu GUL BAYKALIR, Fatih Ahmet KORKAK, Betul DAGOGLU HARK, Gurdal DAGOGLU
Formato:	article
Lenguaje:	EN
Publicado:	University of Kafkas 2021
Materias:	atractyloside gc-ms rat serum xanthium strumarium l. Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/13fb2b063c8f4a28a91411865b23ea04
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spelling	oai:doaj.org-article:13fb2b063c8f4a28a91411865b23ea042021-12-01T07:55:20ZAtractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium10.9775/kvfd.2021.259211300-60451309-2251https://doaj.org/article/13fb2b063c8f4a28a91411865b23ea042021-09-01T00:00:00Zhttp://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2840.pdfhttps://doaj.org/toc/1300-6045https://doaj.org/toc/1309-2251Atractyloside (ATR) may cause severe liver and kidney damage. However, there is a lack of information about levels of ATR in parts of Xanthium strumarium and the concentrations and kinetics of ATR in the serum. In this study, we determined atractyloside levels in Xanthium strumarium parts, its serum concentrations and some kinetic parameters concerning time with the gas chromatography-mass selective (GCMS) method. After administering (80 mg/kg ATR) X. strumarium seed extract to rats through gastric gavage, blood samples were collected at the 0th, 4th, 6th, 8th, 12th, 24th, 36th, 48th, 60th, 72nd, 96th, and 120th h. After extraction, hydrolysis and derivatization of the plant and serum samples were analyzed by the GC-MS instrument. The ATR level in the X. strumarium seeds was 3.043 mg/g in August, 3.502 mg/g in September and 3.800 mg/g in October. ATR was not detected in other parts of the plant. After ATR administration to rats, the Cmax value of ATR was calculated as 10.77 µg/mL at Tmax of 48 h and t1/2 of 6.07 h. A thorough understanding of ATR circulation in the blood will aid in determining the course of its toxic effects in the bloodstream, the onset of symptoms and the general management plan for ATR poisoning. Moreover, the results obtained from this study will contribute to the antidote studies for ATR poisoning.Yasin OZTURKZeliha KESKINSadettin TANYILDIZIBurcu GUL BAYKALIRFatih Ahmet KORKAKBetul DAGOGLU HARKGurdal DAGOGLUUniversity of Kafkasarticleatractylosidegc-msratserumxanthium strumarium l.Veterinary medicineSF600-1100ENKafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 5, Pp 589-594 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atractyloside gc-ms rat serum xanthium strumarium l. Veterinary medicine SF600-1100
spellingShingle	atractyloside gc-ms rat serum xanthium strumarium l. Veterinary medicine SF600-1100 Yasin OZTURK Zeliha KESKIN Sadettin TANYILDIZI Burcu GUL BAYKALIR Fatih Ahmet KORKAK Betul DAGOGLU HARK Gurdal DAGOGLU Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium
description	Atractyloside (ATR) may cause severe liver and kidney damage. However, there is a lack of information about levels of ATR in parts of Xanthium strumarium and the concentrations and kinetics of ATR in the serum. In this study, we determined atractyloside levels in Xanthium strumarium parts, its serum concentrations and some kinetic parameters concerning time with the gas chromatography-mass selective (GCMS) method. After administering (80 mg/kg ATR) X. strumarium seed extract to rats through gastric gavage, blood samples were collected at the 0th, 4th, 6th, 8th, 12th, 24th, 36th, 48th, 60th, 72nd, 96th, and 120th h. After extraction, hydrolysis and derivatization of the plant and serum samples were analyzed by the GC-MS instrument. The ATR level in the X. strumarium seeds was 3.043 mg/g in August, 3.502 mg/g in September and 3.800 mg/g in October. ATR was not detected in other parts of the plant. After ATR administration to rats, the Cmax value of ATR was calculated as 10.77 µg/mL at Tmax of 48 h and t1/2 of 6.07 h. A thorough understanding of ATR circulation in the blood will aid in determining the course of its toxic effects in the bloodstream, the onset of symptoms and the general management plan for ATR poisoning. Moreover, the results obtained from this study will contribute to the antidote studies for ATR poisoning.
format	article
author	Yasin OZTURK Zeliha KESKIN Sadettin TANYILDIZI Burcu GUL BAYKALIR Fatih Ahmet KORKAK Betul DAGOGLU HARK Gurdal DAGOGLU
author_facet	Yasin OZTURK Zeliha KESKIN Sadettin TANYILDIZI Burcu GUL BAYKALIR Fatih Ahmet KORKAK Betul DAGOGLU HARK Gurdal DAGOGLU
author_sort	Yasin OZTURK
title	Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium
title_short	Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium
title_full	Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium
title_fullStr	Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium
title_full_unstemmed	Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium
title_sort	atractyloside levels in xanthium strumarium and atractyloside concentrations in the serum of rats given xanthium strumarium
publisher	University of Kafkas
publishDate	2021
url	https://doaj.org/article/13fb2b063c8f4a28a91411865b23ea04
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Atractyloside Levels in Xanthium strumarium and Atractyloside Concentrations in the Serum of Rats Given Xanthium strumarium

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