Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

Abstract Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulati...

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Autores principales:	Bernardete F. Melo, Jesus Prieto-Lloret, Marlene D. Cabral, Fatima O. Martins, Inês B. Martins, Joana F. Sacramento, Pedro Ruivo, Tânia Carvalho, Silvia V. Conde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13fb3cca865744c1b8428bc65cc74583
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spelling	oai:doaj.org-article:13fb3cca865744c1b8428bc65cc745832021-12-02T13:18:01ZType 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery10.1038/s41598-021-85606-72045-2322https://doaj.org/article/13fb3cca865744c1b8428bc65cc745832021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85606-7https://doaj.org/toc/2045-2322Abstract Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulation and the mechanisms promoting the dysfunction, using pulmonary artery (PA) and aorta. A high-fat (HF, 3 weeks 60% lipid-rich diet) and a high-fat/high-sucrose (HFHSu, combined 60% lipid-rich diet and 35% sucrose during 25 weeks) groups were used as prediabetes and T2D rat models. We found that T2D progression differently affects endothelial function and vascular contractility in the aorta and PA, with the contractile machinery being altered in the PA and aorta in prediabetes and T2D animals; and endothelial function being affected in both models in the aorta but only affected in the PA of T2D animals, meaning that PA is more resistant than aorta to endothelial dysfunction. Additionally, PA and systemic endothelial dysfunction in diabetic rats were associated with alterations in the nitrergic system and inflammatory pathways. PA dysfunction in T2D involves endothelial wall mineralization. The understanding of the mechanisms behind PA dysfunction in T2D can lead to significant advances in both preventative and therapeutic treatments of pulmonary disease-associated diabetes.Bernardete F. MeloJesus Prieto-LloretMarlene D. CabralFatima O. MartinsInês B. MartinsJoana F. SacramentoPedro RuivoTânia CarvalhoSilvia V. CondeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernardete F. Melo Jesus Prieto-Lloret Marlene D. Cabral Fatima O. Martins Inês B. Martins Joana F. Sacramento Pedro Ruivo Tânia Carvalho Silvia V. Conde Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
description	Abstract Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulation and the mechanisms promoting the dysfunction, using pulmonary artery (PA) and aorta. A high-fat (HF, 3 weeks 60% lipid-rich diet) and a high-fat/high-sucrose (HFHSu, combined 60% lipid-rich diet and 35% sucrose during 25 weeks) groups were used as prediabetes and T2D rat models. We found that T2D progression differently affects endothelial function and vascular contractility in the aorta and PA, with the contractile machinery being altered in the PA and aorta in prediabetes and T2D animals; and endothelial function being affected in both models in the aorta but only affected in the PA of T2D animals, meaning that PA is more resistant than aorta to endothelial dysfunction. Additionally, PA and systemic endothelial dysfunction in diabetic rats were associated with alterations in the nitrergic system and inflammatory pathways. PA dysfunction in T2D involves endothelial wall mineralization. The understanding of the mechanisms behind PA dysfunction in T2D can lead to significant advances in both preventative and therapeutic treatments of pulmonary disease-associated diabetes.
format	article
author	Bernardete F. Melo Jesus Prieto-Lloret Marlene D. Cabral Fatima O. Martins Inês B. Martins Joana F. Sacramento Pedro Ruivo Tânia Carvalho Silvia V. Conde
author_facet	Bernardete F. Melo Jesus Prieto-Lloret Marlene D. Cabral Fatima O. Martins Inês B. Martins Joana F. Sacramento Pedro Ruivo Tânia Carvalho Silvia V. Conde
author_sort	Bernardete F. Melo
title	Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_short	Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_full	Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_fullStr	Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_full_unstemmed	Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_sort	type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13fb3cca865744c1b8428bc65cc74583
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Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

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