Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that associate with methylation variation via POE and the...

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Autores principales: Yanni Zeng, Carmen Amador, Charley Xia, Riccardo Marioni, Duncan Sproul, Rosie M. Walker, Stewart W. Morris, Andrew Bretherick, Oriol Canela-Xandri, Thibaud S. Boutin, David W. Clark, Archie Campbell, Konrad Rawlik, Caroline Hayward, Reka Nagy, Albert Tenesa, David J. Porteous, James F. Wilson, Ian J. Deary, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/13fb59ef0899422fa835edb1cbd7b338
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spelling oai:doaj.org-article:13fb59ef0899422fa835edb1cbd7b3382021-12-02T15:35:30ZParent of origin genetic effects on methylation in humans are common and influence complex trait variation10.1038/s41467-019-09301-y2041-1723https://doaj.org/article/13fb59ef0899422fa835edb1cbd7b3382019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09301-yhttps://doaj.org/toc/2041-1723Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that associate with methylation variation via POE and their potential phenotypic consequences.Yanni ZengCarmen AmadorCharley XiaRiccardo MarioniDuncan SproulRosie M. WalkerStewart W. MorrisAndrew BretherickOriol Canela-XandriThibaud S. BoutinDavid W. ClarkArchie CampbellKonrad RawlikCaroline HaywardReka NagyAlbert TenesaDavid J. PorteousJames F. WilsonIan J. DearyKathryn L. EvansAndrew M. McIntoshPau NavarroChris S. HaleyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yanni Zeng
Carmen Amador
Charley Xia
Riccardo Marioni
Duncan Sproul
Rosie M. Walker
Stewart W. Morris
Andrew Bretherick
Oriol Canela-Xandri
Thibaud S. Boutin
David W. Clark
Archie Campbell
Konrad Rawlik
Caroline Hayward
Reka Nagy
Albert Tenesa
David J. Porteous
James F. Wilson
Ian J. Deary
Kathryn L. Evans
Andrew M. McIntosh
Pau Navarro
Chris S. Haley
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
description Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that associate with methylation variation via POE and their potential phenotypic consequences.
format article
author Yanni Zeng
Carmen Amador
Charley Xia
Riccardo Marioni
Duncan Sproul
Rosie M. Walker
Stewart W. Morris
Andrew Bretherick
Oriol Canela-Xandri
Thibaud S. Boutin
David W. Clark
Archie Campbell
Konrad Rawlik
Caroline Hayward
Reka Nagy
Albert Tenesa
David J. Porteous
James F. Wilson
Ian J. Deary
Kathryn L. Evans
Andrew M. McIntosh
Pau Navarro
Chris S. Haley
author_facet Yanni Zeng
Carmen Amador
Charley Xia
Riccardo Marioni
Duncan Sproul
Rosie M. Walker
Stewart W. Morris
Andrew Bretherick
Oriol Canela-Xandri
Thibaud S. Boutin
David W. Clark
Archie Campbell
Konrad Rawlik
Caroline Hayward
Reka Nagy
Albert Tenesa
David J. Porteous
James F. Wilson
Ian J. Deary
Kathryn L. Evans
Andrew M. McIntosh
Pau Navarro
Chris S. Haley
author_sort Yanni Zeng
title Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
title_short Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
title_full Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
title_fullStr Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
title_full_unstemmed Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
title_sort parent of origin genetic effects on methylation in humans are common and influence complex trait variation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/13fb59ef0899422fa835edb1cbd7b338
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