Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli

Abstract Topoisomerase IV (TopoIV) is a vital bacterial enzyme which disentangles newly replicated DNA and enables segregation of daughter chromosomes. In bacteria, DNA replication and segregation are concurrent processes. This means that TopoIV must continually remove inter-DNA linkages during repl...

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Autores principales: Emily Helgesen, Frank Sætre, Kirsten Skarstad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/13fcba975ef245dcaeeacf34ab761619
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