Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter

Both hepatitis C virus (HCV) infection and retinol-binding protein 4 (RBP4) might contribute to insulin resistance (IR), how RBP4 links to IR in HCV infection remain elusive. A joint study of a prospective cohort of 842 chronically HCV-infected (CHC) patients (with 842 controls) and a line of HCV co...

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Autores principales:	Ming-Ling Chang, Wei-Ting Chen, Jing-Hong Hu, Shiang-Chi Chen, Po-Wen Gu, Rong-Nan Chien
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	hcv rbp4 steatosis inflammation insulin resistance homa-ir Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/13fd58480e8541e28c7a4d7972c4f18b
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spelling	oai:doaj.org-article:13fd58480e8541e28c7a4d7972c4f18b2021-11-17T14:21:59ZAltering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter2150-55942150-560810.1080/21505594.2020.1838742https://doaj.org/article/13fd58480e8541e28c7a4d7972c4f18b2020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1838742https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Both hepatitis C virus (HCV) infection and retinol-binding protein 4 (RBP4) might contribute to insulin resistance (IR), how RBP4 links to IR in HCV infection remain elusive. A joint study of a prospective cohort of 842 chronically HCV-infected (CHC) patients (with 842 controls) and a line of HCV core transgenic mice was conducted. Of 842 patients, 771 had completed anti-HCV therapy and 667 had sustained virological responses (SVRs). Compared with controls, CHC patients had lower RBP4 levels. At baseline, age (95% CI β: −0.87~−0.317), BMI (0.516~2.036), triglycerides (0.03~0.127), neutrophil-to-lymphocyte ratio (NLR) (1.561~7.327), and estimated glomerular filtration rate (eGFR) (−0.342~−0.149) levels were associated with RBP4 levels in CHC patients. At 24-week post-therapy, male sex (0.652~8.129), BMI (0.199~1.254), triglycerides (0.039~0.088), uric acid (0.599~3.067), eGFR (−0.247 ~−0.14) levels, and fibrosis-4 (−3.602~−0.039) scores were associated with RBP4 levels in SVR patients; compared with baseline, except genotype 3 HCV-infected patients, SVR patients had increased RBP4 levels, which were comparable with controls, while no HOMA-IR index alteration was noted after SVR. The HCV core transgenic mice exhibited nonobese hepatic steatosis, had higher hepatic RBP4 expression, higher serum levels of RBP4 and triglycerides, but comparable HOMA-IR levels than non-transgenic littermates. In conclusion, steatosis, sex, age, uric acid, NLR, and FIB-4 levels were associated with HCV-related RBP4 levels; BMI, triglycerides, and eGFR levels were associated with non-HCV-related RBP4 levels. Reversal of low RBP4 levels after SVR was evident in non-genotype 3 HCV-infected patients. Steatosis and inflammation linked with metabolic alteration other than IR, determined RBP4 levels in HCV-infected patients.Ming-Ling ChangWei-Ting ChenJing-Hong HuShiang-Chi ChenPo-Wen GuRong-Nan ChienTaylor & Francis Grouparticlehcvrbp4steatosisinflammationinsulin resistancehoma-irInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1501-1511 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hcv rbp4 steatosis inflammation insulin resistance homa-ir Infectious and parasitic diseases RC109-216
spellingShingle	hcv rbp4 steatosis inflammation insulin resistance homa-ir Infectious and parasitic diseases RC109-216 Ming-Ling Chang Wei-Ting Chen Jing-Hong Hu Shiang-Chi Chen Po-Wen Gu Rong-Nan Chien Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter
description	Both hepatitis C virus (HCV) infection and retinol-binding protein 4 (RBP4) might contribute to insulin resistance (IR), how RBP4 links to IR in HCV infection remain elusive. A joint study of a prospective cohort of 842 chronically HCV-infected (CHC) patients (with 842 controls) and a line of HCV core transgenic mice was conducted. Of 842 patients, 771 had completed anti-HCV therapy and 667 had sustained virological responses (SVRs). Compared with controls, CHC patients had lower RBP4 levels. At baseline, age (95% CI β: −0.87~−0.317), BMI (0.516~2.036), triglycerides (0.03~0.127), neutrophil-to-lymphocyte ratio (NLR) (1.561~7.327), and estimated glomerular filtration rate (eGFR) (−0.342~−0.149) levels were associated with RBP4 levels in CHC patients. At 24-week post-therapy, male sex (0.652~8.129), BMI (0.199~1.254), triglycerides (0.039~0.088), uric acid (0.599~3.067), eGFR (−0.247 ~−0.14) levels, and fibrosis-4 (−3.602~−0.039) scores were associated with RBP4 levels in SVR patients; compared with baseline, except genotype 3 HCV-infected patients, SVR patients had increased RBP4 levels, which were comparable with controls, while no HOMA-IR index alteration was noted after SVR. The HCV core transgenic mice exhibited nonobese hepatic steatosis, had higher hepatic RBP4 expression, higher serum levels of RBP4 and triglycerides, but comparable HOMA-IR levels than non-transgenic littermates. In conclusion, steatosis, sex, age, uric acid, NLR, and FIB-4 levels were associated with HCV-related RBP4 levels; BMI, triglycerides, and eGFR levels were associated with non-HCV-related RBP4 levels. Reversal of low RBP4 levels after SVR was evident in non-genotype 3 HCV-infected patients. Steatosis and inflammation linked with metabolic alteration other than IR, determined RBP4 levels in HCV-infected patients.
format	article
author	Ming-Ling Chang Wei-Ting Chen Jing-Hong Hu Shiang-Chi Chen Po-Wen Gu Rong-Nan Chien
author_facet	Ming-Ling Chang Wei-Ting Chen Jing-Hong Hu Shiang-Chi Chen Po-Wen Gu Rong-Nan Chien
author_sort	Ming-Ling Chang
title	Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter
title_short	Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter
title_full	Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter
title_fullStr	Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter
title_full_unstemmed	Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter
title_sort	altering retinol binding protein 4 levels in hepatitis c: inflammation and steatosis matter
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/13fd58480e8541e28c7a4d7972c4f18b
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Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter

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